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Review
. 2024 Jan;113(1):1-10.
doi: 10.1007/s00392-023-02155-x. Epub 2023 Jan 16.

Characteristics and outcomes of patients undergoing transcatheter mitral valve replacement with the Tendyne system

Nihal Wilde #  1 , Tetsu Tanaka #  2 , Vivian Vij  1 , Atsushi Sugiura  1 , Mitsumasa Sudo  1 , Eva Eicheler  1 , Miriam Silaschi  3 , Johanna Vogelhuber  1 , Farhad Bakhtiary  3 , Georg Nickenig  1 , Marcel Weber #  1 , Sebastian Zimmer #  1
Affiliations
Review

Characteristics and outcomes of patients undergoing transcatheter mitral valve replacement with the Tendyne system

Nihal Wilde et al. Clin Res Cardiol. 2024 Jan.

Erratum in

Abstract

Background: Transcatheter mitral valve replacement (TMVR) has emerged as alternative to transcatheter edge-to-edge repair (TEER) for treatment of mitral regurgitation (MR); however, the role of TMVR with the Tendyne system among established treatments of MR is not well defined. We assessed characteristics and outcomes of patients treated with the Tendyne system in the current clinical practice.

Methods: We reviewed patients who underwent cardiac computed tomography and were judged eligible for the Tendyne system.

Results: A total of 63 patients were eligible for TMVR with the Tendyne system. Of these, 17 patients underwent TMVR, and 46 were treated by TEER. Patients treated with the Tendyne system were more likely to have a high transmitral pressure gradient and unsuitable mitral valve morphology for TEER than those treated with TEER. TMVR with the Tendyne system reduced the severity of MR to less than 1 + in 94.1% of the patients at discharge and achieved a greater reduction in left ventricular (LV) end-diastolic volume at the 30-day follow-up compared with TEER. In contrast, patients treated with the Tendyne system had a higher 30-day mortality than those treated with TEER, while the mortality between 30 days and one year was comparable between Tendyne and TEER.

Conclusions: Among patients eligible for the Tendyne system, approximately a quarter of the patients underwent TMVR with the Tendyne system, which led substantial reduction of MR and LV reverse remodeling than TEER. In contrast, the 30-day mortality rate was higher after TMVR with the Tendyne compared to TEER.

Keywords: Mitral regurgitation; Mitral valve disease; Tendyne system; Transcatheter edge-to-edge repair; Transcatheter mitral valve replacement.

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Conflict of interest statement

Tetsu Tanaka has been financially supported in part by a Fellowship from the Japanese College of Cardiology and the Uehara Memorial Foundation. Atsushi Sugiura has received honoraria for lectures from Edwards Lifesciences. Georg Nickenig and Sebastian Zimmer have received research funding from the Deutsche Forschungsgemeinschaft, the German Federal Ministry of Education and Research, the EU, Abbott, Edwards Lifesciences, and Medtronic, and have received honoraria for lectures or advisory boards from Abbott, Edwards Lifesciences, and Medtronic. Marcel Weber has received lecture or proctoring fees from Abbott and Edwards Lifesciences. Miriam Silaschi has received a research grant from Medtronic. The other authors have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Study flowchart. CT  computed tomography, TMVR  transcatheter mitral valve replacement, TEER  transcatheter edge-to-edge repair
Fig. 2
Fig. 2
Changes in the severity of mitral regurgitation after the procedure. The severity of mitral regurgitation at baseline, post-procedure, and 30 days after the procedure in the Tendyne and transcatheter edge-to-edge repair (TEER) groups
Fig. 3
Fig. 3
Changes in left ventricular end-diastolic volume after procedure. Changes in left ventricular (LV) end-diastolic volumes from baseline to the one-month follow-up in the Tendyne and TEER groups
Fig. 4
Fig. 4
Changes in the New York Heart Association functional class after transcatheter mitral valve intervention. Stacked diagram of the New York Heart Association (NYHA) functional class at baseline and the last follow-up. TEER  transcatheter edge-to-edge repair
Fig. 5
Fig. 5
Inverse probability of treatment weighting-adjusted Kaplan–Meier curves of all-cause mortality. Inverse probability of treatment weighting-adjusted Kaplan–Meier curves of all-cause mortality within one year (A), up to 30 days, and between 30 days to one year (B) in the Tendyne and transcatheter edge-to-edge repair (TEER) groups
See this image and copyright information in PMC

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