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. 2023 May 31;38(6):1560-1563.
doi: 10.1093/ndt/gfad004.

Use of kidney injury molecule-1 for sepsis-associated acute kidney injury staging

Luca Molinari  1   2 , Douglas P Landsittel  3 , John A Kellum  1 ; ProCESS and ProGReSS-AKI Investigators*
Collaborators, Affiliations

Use of kidney injury molecule-1 for sepsis-associated acute kidney injury staging

Luca Molinari et al. Nephrol Dial Transplant. .
No abstract available

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Conflict of interest statement

J.A.K. discloses research support and consulting fees from Astute Medical and Astute Medical has licensed unrelated technology from the University of Pittsburgh. Astute Medical is now part of bioMérieux. None of the other authors declare any conflict of interests.

Figures

Figure 1:
Figure 1:
Survival by new AKI stages. The figure shows the Kaplan–Meier curves for survival up to 30 days stratified for the new AKI stages based on urinary KIM-1 ≤4 or >4.0 ng/mL. Dashed lines indicate biomarker-negative patients and solid lines indicate those who were biomarker positive. Blue lines: no AKI/stage 1S; green: stage 1A/B; orange: stage 2A/B; red: 3A/B (for details about the definition of stages refer to reference [2]). Below the figure are the numbers of patients at risk of death at the beginning of Day 0, 10, 20 and 30 from enrollment. The Log-rank test showed P = .001. Pairwise comparison between survival curves within the same functional stage were as follows: no AKI vs stage 1S (P = .03), stage 1A vs 1B (P = .82), stage 2A vs 2B (P = .27) and stage 3A vs 3B (P = .02).
See this image and copyright information in PMC

References

    1. Molinari L, Del Rio-Pertuz G, Smith A.et al. Utility of biomarkers for sepsis-associated acute kidney injury staging. JAMA Network Open 2022;5:e2212709. - PMC - PubMed
    1. Ostermann M, Zarbock A, Goldstein S.et al. Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: a consensus statement. JAMA Network Open 2020;3:e2019209. - PubMed
    1. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl 2012;2:1–138.
    1. Yealy DM, Kellum JA, Huang DT.et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014;370:1683–93. - PMC - PubMed
    1. Kellum JA, Chawla LS, Keener C.et al. The effects of alternative resuscitation strategies on acute kidney injury in patients with septic shock. Am J Respir Crit Care Med 2016;193:281–7. - PMC - PubMed

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