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. 2023 Mar;41(3):276-277.
doi: 10.1016/j.tibtech.2023.01.002. Epub 2023 Jan 14.

Engineered membrane receptors with customizable input and output functions

Justin A Peruzzi  1 , Timothy Q Vu  2 , Neha P Kamat  3
Affiliations

Engineered membrane receptors with customizable input and output functions

Justin A Peruzzi et al. Trends Biotechnol. 2023 Mar.

Abstract

Morsut et al. reported a synthetic receptor system, based on the natural Notch receptor, with customizable input and output functions. Their work on advanced receptor design expands the reach of synthetic receptor systems. Incorporating new protein design tools with better-understood membrane biophysics will create the next generation of engineered receptors.

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Conflict of interest statement

Declaration of interests No interests are declared.

Figures

Figure 1.
Figure 1.. Membrane biophysical features could be used to enhance the capabilities of engineered receptor systems.
(Left) SynNotch enables cells to sense new inputs and respond to them in novel ways. (Right) By considering membrane biophysical features, such as lipid–protein and protein–protein interactions, in the design of next generation transmembrane sensors, expanded sensing capabilities may be achieved.
See this image and copyright information in PMC

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