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Comment
. 2023 Jan 16;8(1):34.
doi: 10.1038/s41392-022-01307-1.

Landscape of antitumor CD4+ T cells in melanoma:unraveling novel HLA class II-driven immune escape

Xiangjie Xue  1 , Ji Wang  2 , Chenyang Ye  3   4
Affiliations
Comment

Landscape of antitumor CD4+ T cells in melanoma:unraveling novel HLA class II-driven immune escape

Xiangjie Xue et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Novel mechanism of melanoma HLA class II-driven immune escape. With the assistance of indirect antitumor CD4+ Treg cells presented by Antigen-presenting cells (APCs), and direct antitumor Treg cells (major tumor-reactive cells), HLA class II positive melanoma cells evade immune surveillance. In addition, Melanoma directly induced cytotoxic CD4+ T cells depletion through HLA class I, but not directly induced Treg production through HLA class I. The figure was generated on Biorender.com
See this image and copyright information in PMC

Comment on

  • Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.
    Oliveira G, Stromhaug K, Cieri N, Iorgulescu JB, Klaeger S, Wolff JO, Rachimi S, Chea V, Krause K, Freeman SS, Zhang W, Li S, Braun DA, Neuberg D, Carr SA, Livak KJ, Frederick DT, Fritsch EF, Wind-Rotolo M, Hacohen N, Sade-Feldman M, Yoon CH, Keskin DB, Ott PA, Rodig SJ, Boland GM, Wu CJ. Oliveira G, et al. Nature. 2022 May;605(7910):532-538. doi: 10.1038/s41586-022-04682-5. Epub 2022 May 4. Nature. 2022. PMID: 35508657 Free PMC article.

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