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Published Erratum
. 2023 Jan 16;13(1):826.
doi: 10.1038/s41598-022-26917-1.

Author Correction: Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

Carmen Noelker  1   2 , Lydie Morel  1 , Thomas Lescot  1 , Anke Osterloh  3 , Daniel Alvarez-Fischer  1   2 , Minka Breloer  3 , Carmen Henze  1 , Candan Depboylu  2 , Delphine Skrzydelski  1 , Patrick P Michel  1 , Richard C Dodel  2 , Lixia Lu  1 , Etienne C Hirsch  1 , Stéphane Hunot  4 , Andreas Hartmann  5
Affiliations
Published Erratum

Author Correction: Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

Carmen Noelker et al. Sci Rep. .
No abstract available

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Figures

Figure 1
Figure 1
(A): HPLC measurement of striatal dopamine (DA) and homovanillic acid (HVA) levels, as well as calculation of the HVA/DA-ratio after MPTP-intoxication of TLR4- deficient (TLR def) and WT mice in comparison to saline treated mice. Values are expressed as mean ± SEM (*p < 0.05 comparing MPTP treated group with its saline control, #p < 0.05 comparing MPTP-treated groups of WT and TLR4-deficient mice. (B): TH-positive cell number in SN after MPTP treatment. WT = WT mice, TLR deficient = TLR4 deficient mice. Values are expressed as mean ± SEM (*p < 0.05 comparing MPTP treated group with its saline control). (C): Representative photographs of the SN of each treatment group is shown. TH-staining of free-floating cryomicrotome-cut sections at day 7. TLR4-deficient = TLR4-deficient mice, WT = wild-type mice. Control = saline treated mice, MPTP = MPTP-treated mice, Scale bars = 200 μm.
Figure 2
Figure 2
(A): Number of nigral Iba+ microglia at day 2 and day 7. WT = WT mice, TLR def = TLR4-deficient mice. Values are expressed as mean ± SEM (*p < 0.05 comparing MPTP-treated group with its saline control, #p < 0.05 comparing MPTP-treated groups of WT and TLR4-deficient mice). (B): MHC II+ cell number in SN after MPTP treatment at day 2. WT = WT mice, TLR def = TLR4-deficient mice. Values are expressed as mean ± SEM (*p < 0.05 comparing MPTP-treated group with its saline control, #p < 0.05 comparing MPTP-treated groups of WT and TLR4-deficient mice). (C): Representative photographs of the SN (Iba-1 staining) of each treatment group at day 2 are shown. TLR4 def = TLR4-deficient mice, WT = wild-type mice. Control = saline treated mice, MPTP = MPTP treated mice. Scale bars = 200 μm. (D): Correlation analysis of TH+- and Iba+-positive cells counts at day 7 in SNpc (r = −0.92, p < 0.001).
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