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. 2023 Mar;22(3):165-166.
doi: 10.1038/d41573-023-00014-y.

Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Francesco Marchetti et al. Nat Rev Drug Discov. 2023 Mar.
No abstract available

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References

    1. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011). - PubMed - DOI
    1. Salk, J. J., Schmitt, M. W. & Loeb, L. A. Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations. Nat. Rev. Genet. 19, 269–285, (2018). - PubMed - DOI - PMC
    1. Wang, Y. et al. Genetic toxicity testing using human in vitro organotypic airway cultures: assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing. Environ. Mol. Mutagen. 62, 306–318 (2021). - PubMed - DOI - PMC
    1. Valentine, C. C. III et al. Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing. Proc. Natl Acad. Sci. USA 117, 33414–33425 (2020). - PubMed - DOI - PMC
    1. Fielden, M. R. et al. Modernizing human cancer risk assessment of therapeutics. Trends Pharmacol. Sci. 39, 232–247 (2018). - PubMed - DOI

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