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Comment
. 2023 Feb;55(2):168-169.
doi: 10.1038/s41588-022-01255-0.

Dissecting endometriosis by single-cell transcriptomic and genomic analysis

No authors listed
Comment

Dissecting endometriosis by single-cell transcriptomic and genomic analysis

No authors listed. Nat Genet. 2023 Feb.
No abstract available

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Comment on

  • Single-cell transcriptomic analysis of endometriosis.
    Fonseca MAS, Haro M, Wright KN, Lin X, Abbasi F, Sun J, Hernandez L, Orr NL, Hong J, Choi-Kuaea Y, Maluf HM, Balzer BL, Fishburn A, Hickey R, Cass I, Goodridge HS, Truong M, Wang Y, Pisarska MD, Dinh HQ, El-Naggar A, Huntsman DG, Anglesio MS, Goodman MT, Medeiros F, Siedhoff M, Lawrenson K. Fonseca MAS, et al. Nat Genet. 2023 Feb;55(2):255-267. doi: 10.1038/s41588-022-01254-1. Epub 2023 Jan 9. Nat Genet. 2023. PMID: 36624343 Free PMC article.

References

    1. Fonseca, M. A. S. et al. Single cell transcriptomic analysis of endometriosis. Nat. Genet. https://doi.org/10.1038/10.1038/s41588-022-01254-1 (2022). A paper that reports single-cell transcriptomic analysis of ~50 tissues from 17 patients with endometriosis and four individuals who are unaffected. - DOI - PubMed - PMC
    1. Tan, Y. et al. Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues. Nat. Cell Biol. 24, 1306–1318 (2022). This paper reports single-cell transcriptomic analyses of endometriosis in patients taking exogenous hormones, with a focus on the perivascular niche, and immune signatures of the peritoneum in affected individuals. - DOI - PubMed
    1. Garcia-Alonso, L. et al. Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro. Nat. Genet. 53, 1698–1711 (2021). This study performed scRNA-seq and spatial profiling of endometrium and endometrial organoids that were exposed to ovarian hormones, and relates epithelial signatures to endometrial cancer and endometriosis. - DOI - PubMed - PMC
    1. Wang, W. et al. Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle. Nat. Med. 26, 1644–1653 (2020). A single-cell transcriptomic study of the endometrium throughout the menstrual cycle, with a focus on the window of implantation. - DOI - PubMed

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