Evaluation of diagnostic time in pediatric patients with eosinophilic gastrointestinal disorders according to their clinical features
- PMID: 36647148
- PMCID: PMC9841131
- DOI: 10.1186/s13052-023-01410-1
Evaluation of diagnostic time in pediatric patients with eosinophilic gastrointestinal disorders according to their clinical features
Abstract
Eosinophilic gastrointestinal disorders (EGIDs) are chronic/remittent inflammatory diseases associated with a substantial diagnostic delay, often attributable to misdiagnosis and variable clinical presentation in adults. In the pediatric population, few studies have been conducted worldwide reporting EGID diagnostic delay and its consequences on patients. This study aims to analyze and identify potential clinical factors and complications associated with a longer diagnostic time. We performed a retrospective analysis of pediatric patients with EGIDs followed at the Center for Pediatric EGIDs in Pavia, Italy. A total of 60 patients with EGIDs were enrolled. Thirty-nine (65%) patients had EoE, and 21 (35%) non-esophageal EGIDs. EGID diagnosis was achieved about 2 years after the symptom onset, and the median diagnostic time was 12 months (IQR 12-24 months). Diagnostic time was 12 months (IQR 12-69) in non-esophageal EGIDs and 12 months (IQR 4-24 months) in EoE patients. EoE patients presenting with FTT and feeding issues experienced a longer diagnostic time (p = 0.02 and p = 0.05, respectively) than children without growth and feeding impairments.In this study, symptoms appeared about 2 years before the definitive EGID diagnosis was reached, and this diagnostic time was shorter than the delay observed in other published studies. Especially in EoE children, the diagnostic time is significantly associated with impaired child growth, highlighting the importance of an early diagnosis to prevent esophageal stenosis and failure to thrive.
Keywords: Adolescents; Children; Diagnostic time; Eosinophilic esophagitis; Failure to thrive; Growth; Non-esophageal eosinophilic gastrointestinal disorders.
© 2023. The Author(s).
Conflict of interest statement
The authors declare that they have no competing interests.
Figures

Similar articles
-
Eosinophilic gastrointestinal disorders in children and adolescents: A single-center experience.Dig Liver Dis. 2022 Feb;54(2):214-220. doi: 10.1016/j.dld.2021.06.027. Epub 2021 Jul 15. Dig Liver Dis. 2022. PMID: 34274254
-
Comparison of Nonesophageal Eosinophilic Gastrointestinal Disorders with Eosinophilic Esophagitis: A Nationwide Survey.J Allergy Clin Immunol Pract. 2021 Sep;9(9):3339-3349.e8. doi: 10.1016/j.jaip.2021.06.026. Epub 2021 Jun 29. J Allergy Clin Immunol Pract. 2021. PMID: 34214704
-
Early life exposures as risk factors for non-esophageal eosinophilic gastrointestinal diseases.Clin Res Hepatol Gastroenterol. 2023 Aug;47(7):102170. doi: 10.1016/j.clinre.2023.102170. Epub 2023 Jun 21. Clin Res Hepatol Gastroenterol. 2023. PMID: 37352927 Free PMC article.
-
Eosinophilic Gastrointestinal Diseases in Childhood.Ann Nutr Metab. 2018;73 Suppl 4:18-28. doi: 10.1159/000493668. Epub 2019 Feb 19. Ann Nutr Metab. 2018. PMID: 30783041 Review.
-
Common and disparate clinical presentations and mechanisms in different eosinophilic gastrointestinal diseases.J Allergy Clin Immunol. 2024 Jun;153(6):1472-1484. doi: 10.1016/j.jaci.2024.03.013. Epub 2024 Mar 28. J Allergy Clin Immunol. 2024. PMID: 38555071 Free PMC article. Review.
Cited by
-
Disease Burden and Spectrum of Symptoms that Impact Quality of Life in Pediatric Patients with Eosinophilic Esophagitis.Gastro Hep Adv. 2024 Aug 22;3(8):1054-1068. doi: 10.1016/j.gastha.2024.08.009. eCollection 2024. Gastro Hep Adv. 2024. PMID: 39529644 Free PMC article. Review.
-
A Practical Update on Pediatric Eosinophilic Esophagitis.Children (Basel). 2023 Sep 28;10(10):1620. doi: 10.3390/children10101620. Children (Basel). 2023. PMID: 37892285 Free PMC article. Review.
-
Manometric findings in children with eosinophilic esophagitis and persistent post-remission dysphagia.JPGN Rep. 2024 May 22;5(3):289-295. doi: 10.1002/jpr3.12083. eCollection 2024 Aug. JPGN Rep. 2024. PMID: 39149200 Free PMC article.
-
[Research progress on risk factors for poor prognosis in pediatric non-esophageal eosinophilic gastrointestinal disorder].Zhongguo Dang Dai Er Ke Za Zhi. 2025 Apr 15;27(4):493-499. doi: 10.7499/j.issn.1008-8830.2411034. Zhongguo Dang Dai Er Ke Za Zhi. 2025. PMID: 40241370 Free PMC article. Review. Chinese.
-
Barriers to Timely Diagnosis of Eosinophilic Gastrointestinal Diseases.J Allergy Clin Immunol Pract. 2024 Feb;12(2):302-308. doi: 10.1016/j.jaip.2023.12.020. Epub 2023 Dec 17. J Allergy Clin Immunol Pract. 2024. PMID: 38110118 Free PMC article.
References
Publication types
MeSH terms
Supplementary concepts
LinkOut - more resources
Full Text Sources
Medical