Review

. 2023 Jan 16;21(1):27.

doi: 10.1186/s12967-023-03878-1.

Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Ao-Ran Liu^{1

2

3}, Zhi Lv^{1

2

3}, Zi-Wei Yan^{1

2

3}, Xiao-Yang Wu^{1

2

3}, Li-Rong Yan^{1

2

3}, Li-Ping Sun^#^{4

5

6}, Yuan Yuan^#^{7

8

9}, Qian Xu^#^{10

11

12}

Affiliations

¹ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.
² Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China.
³ Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China.
⁴ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. lpsun@cmu.edu.cn.
⁵ Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China. lpsun@cmu.edu.cn.
⁶ Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China. lpsun@cmu.edu.cn.
⁷ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. yuanyuan@cmu.edu.cn.
⁸ Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China. yuanyuan@cmu.edu.cn.
⁹ Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China. yuanyuan@cmu.edu.cn.
¹⁰ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. qxu@cmu.edu.cn.
¹¹ Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China. qxu@cmu.edu.cn.
¹² Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China. qxu@cmu.edu.cn.

^# Contributed equally.

PMID: 36647167
PMCID: PMC9843870
DOI: 10.1186/s12967-023-03878-1

Review

Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Ao-Ran Liu et al. J Transl Med. 2023.

. 2023 Jan 16;21(1):27.

doi: 10.1186/s12967-023-03878-1.

Authors

Ao-Ran Liu^{1

2

3}, Zhi Lv^{1

2

3}, Zi-Wei Yan^{1

2

3}, Xiao-Yang Wu^{1

2

3}, Li-Rong Yan^{1

2

3}, Li-Ping Sun^#^{4

5

6}, Yuan Yuan^#^{7

8

9}, Qian Xu^#^{10

11

12}

Affiliations

¹ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.
² Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China.
³ Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China.
⁴ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. lpsun@cmu.edu.cn.
⁵ Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China. lpsun@cmu.edu.cn.
⁶ Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China. lpsun@cmu.edu.cn.
⁷ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. yuanyuan@cmu.edu.cn.
⁸ Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China. yuanyuan@cmu.edu.cn.
⁹ Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China. yuanyuan@cmu.edu.cn.
¹⁰ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. qxu@cmu.edu.cn.
¹¹ Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China. qxu@cmu.edu.cn.
¹² Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China. qxu@cmu.edu.cn.

^# Contributed equally.

PMID: 36647167
PMCID: PMC9843870
DOI: 10.1186/s12967-023-03878-1

Abstract

Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could affect cellular energy metabolism leading to tumorigenesis. In recent years, disrupted mitochondrial dynamics has been found to influence the biological behaviors of gastrointestinal cancer with the potential to be a novel target for its individualized therapy. This review systematically introduced the role of mitochondrial dynamics in maintaining mitochondrial homeostasis, and further elaborated the effects of disrupted mitochondrial dynamics on the cellular biological behaviors of gastrointestinal cancer as well as its association with cancer progression. We aim to provide clues for elucidating the etiology and pathogenesis of gastrointestinal cancer from the perspective of mitochondrial homeostasis and disorder.

Keywords: Fission; Fusion; Gastrointestinal cancer; Mitochondria; Mitochondrial biogenesis; Mitochondrial dynamic; Mitochondrial homeostasis; Mitochondrial quality control; Mitophagy.

PubMed Disclaimer

Conflict of interest statement

All authors have read the journal’s authorship agreement and policy on disclosure of potential competing interest.

The authors declare that there is no competing interest regarding the publication of this article.

Figures

**Fig. 1**
Mitochondrial homeostasis is maintained by MQC system. Mitochondrial quality control system is composed of the balance between fusion (A) and fission (B), and between biogenesis (C) and mitophagy (D). A. Fusion. Mitochondria mediate fusion of IMM and OMM through OPA1 and MFN1/2. B. Fission. Mitochondria complete fission through fission-related factors such as DRP1 and dynein. C. Mitochondrial biogenesis. AMPK and SIRT1 pathways activate the PGC-1α/NRF1/2/TAFM axis and affect mitochondrial biogenesis. D. Mitophagy. Mitochondrial mitophagy is initiated to eliminate damaged mitochondria generated from disrupted fission and fusion

**Fig. 2**
Disorder in mitochondrial dynamics and gastrointestinal cancer. Disrupted mitochondrial dynamics promotes the cancerization of gastrointestinal cellular biological behaviors, thus participating in the occurrence, development and prognosis of gastrointestinal tumor

See this image and copyright information in PMC

References

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660. - DOI - PubMed
1. Hou XS, Wang HS, Mugaka BP, Yang GJ, Ding Y. Mitochondria: promising organelle targets for cancer diagnosis and treatment. Biomater Sci. 2018;6(11):2786–2797. doi: 10.1039/C8BM00673C. - DOI - PubMed
1. Taylor DE, Kantrow SP, Piantadosi CA. Mitochondrial respiration after sepsis and prolonged hypoxia. Am J Physiol. 1998;275(1):L139–L144. - PubMed
1. Wallace DC, Fan W, Procaccio V. Mitochondrial energetics and therapeutics. Annu Rev Pathol. 2010;5:297–348. doi: 10.1146/annurev.pathol.4.110807.092314. - DOI - PMC - PubMed
1. Galluzzi L, Kepp O, Kroemer G. Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol. 2012;13(12):780–788. doi: 10.1038/nrm3479. - DOI - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Affiliations

Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources