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Review
. 2023 May 24;40(5):964-971.
doi: 10.1039/d2np00082b.

Revisiting the manzamine biosynthetic hypothesis

Alexander T Piwko  1 , Brian G Miller  1 , Joel M Smith  1
Affiliations
Review

Revisiting the manzamine biosynthetic hypothesis

Alexander T Piwko et al. Nat Prod Rep. .

Abstract

Covering: up to 2023The marine environment represents a rich yet challenging source of novel therapeutics. These challenges are best exemplified by the manzamine class of alkaloids, featuring potent bioactivities, difficult procurement, and a biosynthetic pathway that has eluded characterization for over three decades. This review highlights postulated biogenic pathways toward the manzamines, evaluated in terms of current biosynthetic knowledge and metabolic precedent.

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Conflict of interest statement

Conflicts of interest

There are no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Representative manzamine alkaloids.
Fig. 2
Fig. 2
(A) Baldwin and coworkers' hypothesis. (B) Marazano variation.
Fig. 3
Fig. 3
(A) Argimycin PKS (adapted from ref. 49). (B) Postulated haminol PKS and related congeners.
Fig. 4
Fig. 4
Thomas biosynthetic proposal toward the pachychalines (adapted from ref. and 58).
Fig. 5
Fig. 5
Expansion of the polyamine pathway (adapted from ref. 58).
Fig. 6
Fig. 6
Modified biosynthetic pathway toward manzamine A.
See this image and copyright information in PMC

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