Key insights into secondary metabolites from various Chaetomium species

Abstract

Endophytic fungi have proved to be a major source of secondary metabolites, wherein the genus Chaetomium has emerged as a source of multifarious bioactive natural compounds belonging to diverse classes such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, xanthones, anthraquinone, chromones, depsidones, terpenoids, and steroids. The objective of this review is to encapsulate recent findings on various Chaetomium strains, such as C. globosum, C. cupreum, C. elatum, C. subspirale, C. olivaceum, C. indicum, and C. nigricolor known for production of beneficial secondary metabolites, with an insight into their origin and function. A thorough literature survey was conducted for obtaining Chaetomium-derived secondary metabolites, with a scope of future application into drug development efforts. More than 100 secondary metabolites, with various beneficial properties such as antitumor, cytotoxic, antimalarial, and enzyme inhibitory activities, were enlisted. We believe this review will enhance the understanding of beneficial effects conferred by various Chaetomium-derived secondary metabolites and emphasize their potential in serving novel drug development efforts. KEY POINTS: • Identified Chaetomium-derived metabolites with potential for drug development. • More than 100 beneficial metabolites are enlisted. • Benefits include anti-cancerous, antimalarial, and anti-enzymatic properties.

Keywords: Bioactivities; Chaetomium; Drug discovery; Endophytes; Natural products.

Fig. 1

Some of the compounds isolated from Chaetomium globosum

Fig. 2

Some of the compounds isolated from Chaetomium cupreum (22–26), Chaetomium elatum (27–37), and Chaetomium subspirale (38)

Fig. 3

Some of the compounds isolated from Chaetomium olivaceum (39, 40), Chaetomium indicum (41–47), and Chaetomium nigricolor (48, 49)

Fig. 4

Some of the compounds isolated from various Chaetomium species