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Comment
. 2023 Feb;24(2):218-219.
doi: 10.1038/s41590-022-01409-6.

Exhausted T cells in tumors gain suppressor activity and can restrain immunity

No authors listed
Comment

Exhausted T cells in tumors gain suppressor activity and can restrain immunity

No authors listed. Nat Immunol. 2023 Feb.
No abstract available

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References

    1. Wang, H., Franco, F. & Ho, P. C. Metabolic regulation of Tregs in cancer: opportunities for immunotherapy. Trends Cancer 3, 583–592 (2017). A review article that describes the effects of Treg cell infiltration in cancer and therapeutic strategies to subvert them.
    1. Blank, C. U. et al. Defining ‘T cell exhaustion’. Nat. Rev. Immunol. 19, 665–674 (2019). A review article presenting our understanding of the generation and maintenance of T cell exhaustion. - DOI
    1. Miller, B. C. et al. Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade. Nat. Immunol. 20, 326–336 (2019). This paper identifies a subset of exhausted T cells responsive to PD-1 blockade.
    1. Canale, F. P. et al. CD39 expression defines cell exhaustion in tumor-infiltrating CD8+ T cells. Cancer Res. 78, 115–128 (2018). This paper reports CD39 as a key defining marker of terminally exhausted T cells.
    1. Scharping, N. E. et al. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nat. Immunol. 22, 205–215 (2021). This paper defines a key role for hypoxia in accelerating T cell exhaustion. - DOI

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