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. 2023 Apr;597(8):1086-1097.
doi: 10.1002/1873-3468.14572. Epub 2023 Jan 17.

Lipocalin 2 inhibits actin glutathionylation to promote invasion and migration

Bhagya Shree Choudhary  1   2 , Nazia Chaudhary  1   2 , Manya Shah  1 , Nehanjali Dwivedi  3 , Smitha P K  4 , Manjula Das  3 , Sorab Nariman Dalal  1   2
Affiliations
Free article

Lipocalin 2 inhibits actin glutathionylation to promote invasion and migration

Bhagya Shree Choudhary et al. FEBS Lett. 2023 Apr.
Free article

Abstract

Invasive and metastatic tumor cells show an increase in migration and invasion, making the processes contributing to these phenotypes potential therapeutic targets. Lipocalin 2 (LCN2; also known as neutrophil gelatinase-associated lipocalin) is a putative therapeutic target in multiple tumor types and promotes invasion and migration, although the mechanisms underlying these phenotypes are unclear. The data in this report demonstrate that LCN2 promotes actin polymerization, invasion, and migration by inhibiting actin glutathionylation. LCN2 inhibits actin glutathionylation by decreasing the levels of reactive oxygen species (ROS) and by reducing intracellular iron levels. Inhibiting LCN2 function leads to increased actin glutathionylation, decreased migration, and decreased invasion. These results suggest that LCN2 is a potential therapeutic target in invasive tumors.

Keywords: Lipocalin 2; actin; glutathionylation; invasion; neutrophil gelatinase-associated lipocalin.

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