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. 2023 Feb 2;59(11):1461-1464.
doi: 10.1039/d2cc05718b.

Unlike RNA-TBA (rTBA), iso-rTBA, the 2'-5'-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA

Atish A Wagh  1   2 , Vaijayanti A Kumar  1   2 , Sapna Ravindranathan  2   3 , Moneesha Fernandes  1   2
Affiliations

Unlike RNA-TBA (rTBA), iso-rTBA, the 2'-5'-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA

Atish A Wagh et al. Chem Commun (Camb). .

Abstract

An antiparallel, functional RNA G-quadruplex of the 2'-5'-linked thrombin-binding aptamer (iso-rTBA) is reported for the first time. It can inhibit clotting and is remarkably stable to nuclease-degradation, besides having high thermal stability. It is thus, a superior candidate to TBA, rTBA or isoTBA, for further development as an anticoagulant.

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