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. 2022 Apr 13;72(3):359-374.
doi: 10.2478/acph-2022-0027. Print 2022 Sep 1.

Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells

Yoo Kyung Hong  1 , Sungkwan An  1 , Yun Hee Lee  1 , Seung Ah Yang  1 , Yoo Kyung Yoon  1 , Joonil Lee  2 , Gwasoo Lee  2 , Myung Jun Chung  2 , Seunghee Bae  1
Affiliations
Free article

Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells

Yoo Kyung Hong et al. Acta Pharm. .
Free article

Abstract

In this study, the protective functions of bacteria-free conditioned media from Bifidobacterium and Lactobacillus species against ultraviolet radiation-induced skin ageing and associated cellular damage were investigated. The effects of ultraviolet radiation-induced reactive oxygen species production were suppressed by all conditioned media; particularly, the loss of cell viability and downregulation of collagen gene expression were significantly reversed by the conditioned media from B. longum and B. lactis. Further exa mination of potential anti-pigmentation effects revealed that the B. lactis-derived conditioned media significantly inhibited tyrosinase activity and alpha-melanocyte-stimulating hormone-induced melanin production in human epidermal melanocytes. Further, the conditioned media suppressed the phosphorylation of extracellular signal- related kinase, which functions as an upstream regulator of melanogenesis. Therefore, B. lactis-derived conditioned media can potentially protect against cellular damage involved in skin-ageing processes.

Keywords: anti-ageing; anti-pigmentation; conditioned media; probiotics; protection; skin cells.

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