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Review
. 2023 Mar;38(3):359-369.
doi: 10.1002/jbmr.4773. Epub 2023 Feb 3.

Macrophages and Bone Remodeling

Megan M Weivoda  1 , Elizabeth W Bradley  2
Affiliations
Review

Macrophages and Bone Remodeling

Megan M Weivoda et al. J Bone Miner Res. 2023 Mar.

Abstract

Bone remodeling in the adult skeleton facilitates the removal and replacement of damaged and old bone to maintain bone quality. Tight coordination of bone resorption and bone formation during remodeling crucially maintains skeletal mass. Increasing evidence suggests that many cell types beyond osteoclasts and osteoblasts support bone remodeling, including macrophages and other myeloid lineage cells. Herein, we discuss the origin and functions for macrophages in the bone microenvironment, tissue resident macrophages, osteomacs, as well as newly identified osteomorphs that result from osteoclast fission. We also touch on the role of macrophages during inflammatory bone resorption. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

Keywords: INFLAMMATORY BONE LOSS; OSTEOCLAST; OSTEOCLAST FRAGMENTATION; OSTEOMAC; OSTEOMORPHS; OSTEOPOROSIS.

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Figures

Figure 1.
Figure 1.. Origins of macrophages.
(A) Hematopoietic stem cell (HSC)-derived common myeloid progenitors give rise to myocytes, macrophages and osteoclasts. Osteomorphs most like are generated from this lineage as well. Fetal erythro-myeloid progenitors (EMPs) also generate osteoclasts and tissue resident macrophages.
Figure 2.
Figure 2.. Overview of Bone Remodeling.
Known phases and cell types involved in bone remodeling within trabecular bone are shown.
See this image and copyright information in PMC

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