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. 2023 Nov;112(11):1555-1567.
doi: 10.1007/s00392-023-02156-w. Epub 2023 Jan 18.

Adverse cardiovascular and metabolic perturbations among older women: 'fat-craving' hearts

Jien Sze Ho #  1   2 , Jie Jun Wong #  1 , Fei Gao  1   2 , Hai Ning Wee  2 , Louis L Y Teo  1   2 , See Hooi Ewe  1   2 , Ru-San Tan  1   2 , Jianhong Ching  2   3 , Kee Voon Chua  2 , Lye Siang Lee  2 , Woon-Puay Koh  4   5 , Jean-Paul Kovalik  2   6 , Angela S Koh  7   8
Affiliations

Adverse cardiovascular and metabolic perturbations among older women: 'fat-craving' hearts

Jien Sze Ho et al. Clin Res Cardiol. 2023 Nov.

Abstract

Background: Despite known sex-based differences in cardiovascular aging, differences in aging biology are poorly understood. We hypothesize that circulating metabolites studied cross-sectionally with cardiac aging may be associated with cardiovascular changes that distinguish cardiac aging in women.

Methods: A population-based cohort of community men and women without cardiovascular disease from Singapore underwent detailed clinical and echocardiography examinations. Cross-sectional associations between cardiac functional characteristics and metabolomics profiles were examined.

Results: Five hundred sixty-seven adults (48.9% women) participated. Women were younger (72 ± 4.4 years vs 73 ± 4.3 years, p = 0.022), had lower diastolic blood pressures (71 ± 11.0 mmHg vs 76 ± 11.2 mmHg, p < 0.0001, and less likely to have diabetes mellitus (18.0% vs 27.6%, p = 0.013) and smoking (3.8% vs 34.5%, p < 0.001). Body mass indices were similar (24 ± 3.8 kg/m2 vs 24 ± 3.4 kg/m2, p = 0.29), but women had smaller waist circumferences (81 ± 10.1 cm vs 85 ± 9.2 cm, p < 0.001). Women had a significantly higher E/e' ratios (10.9 ± 3.4 vs 9.9 ± 3.3, p = 0.007) and mitral A peak (0.86 ± 0.2 m/s vs 0.79 ± 0.2 m/s, p < 0.001) than men. Among women, lower E/e' ratio was associated with higher levels of C16 (OR 1.019, 95%CI 1.002-1.036, p = 0.029), C16:1 (OR 1.06, 95%CI 1.006-1.118, p = 0.028), serine (OR 1.019, 95%CI 1.002-1.036, p = 0.025), and histidine (OR 1.045, 95%CI 1.013-1.078, p = 0.006). Lower mitral A peak was associated with higher levels of histidine (OR 1.039, 95%CI 1.009-1.070, p = 0.011), isoleucine (OR 1.013, 95%CI 1.004-1.021, p = 0.004), and C20 (OR 1.341, 95%CI 1.067-1.684, p = 0.012).

Conclusion: Impairments in diastolic functions were more frequent among older women compared to men, despite lower prevalence of vascular risk factors and preserved cardiac structure. Cardiac aging in women correlated with metabolites involved in fatty acid oxidation and tricyclic acid cycle fuelling.

Keywords: Aging; Cardiovascular disease; Diastolic function; Heart failure; Metabolomics; Women.

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References

    1. Merz AA, Cheng S (2016) Sex differences in cardiovascular ageing. Heart 102(11):825. https://doi.org/10.1136/heartjnl-2015-308769 - DOI - PubMed
    1. Hayward CS, Kelly RP, Collins P (2000) The roles of gender, the menopause and hormone replacement on cardiovascular function. Cardiovasc Res 46(1):28–49. https://doi.org/10.1016/s0008-6363(00)00005-5 - DOI - PubMed
    1. Swaraj S, Kozor R, Arnott C, Di Bartolo BA, Figtree GA (2021) Heart failure with reduced ejection fraction-does sex matter? Curr Heart Fail Rep 18(6):345–352. https://doi.org/10.1007/s11897-021-00533-y - DOI - PubMed - PMC
    1. Oktay AA, Rich JD, Shah SJ (2013) The emerging epidemic of heart failure with preserved ejection fraction. Curr Heart Fail Rep 10(4):401–410. https://doi.org/10.1007/s11897-013-0155-7 - DOI - PubMed
    1. Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA (2005) Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation 112(15):2254–2262. https://doi.org/10.1161/CIRCULATIONAHA.105.541078 - DOI - PubMed

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