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Review
. 2023 Jul;195(7):4617-4636.
doi: 10.1007/s12010-023-04318-y. Epub 2023 Jan 18.

An Overview of Collagen-Based Composite Scaffold for Bone Tissue Engineering

Ashwathi Vijayalekha  1 , Suresh Kumar Anandasadagopan  2 , Ashok Kumar Pandurangan  3
Affiliations
Review

An Overview of Collagen-Based Composite Scaffold for Bone Tissue Engineering

Ashwathi Vijayalekha et al. Appl Biochem Biotechnol. 2023 Jul.

Abstract

Bone regeneration or restoration is a series of well-ordered physiological activities that occur throughout a person's life, they are continuously being repaired and remodeled. A conventional bone repair procedure, such as autograft and allograft bone transplant, has failed to address bone reconstruction disputes and complexity. On the other hand, Tissue Engineering is a potential therapy option for repairing rather than replacing the damaged tissue. Biomaterials in bone tissue engineering (BTE) help pave the way for damaged tissues as an artificial extracellular matrix, facilitating new tissue growth. Collagen-based biomaterials for repair and replacement have inspired much interest in the hunt for versatile biomaterials compatible with human tissue. It is a major organic component of extracellular matrix in bone and has been employed as scaffolding material in BTE for decades. In this review, we documented the role of collagen in BTE, focusing on collagen type I, its crosslinking capability, collagen-based biomaterials, and fabrication methods. It also considers osteoblast citration a critical process in bone formation, a unique perspective for an old relationship.

Keywords: Bone tissue engineering; Collagen; Crosslinking; Osteoblast citration; Scaffold.

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References

    1. Shoulders, M. D., & Raines, R. T. (2009). Collagen structure and stability. Annual Review of Biochemistry, 78, 929–958. https://doi.org/10.1146/annurev.biochem.77.032207.120833 - DOI - PubMed - PMC
    1. Fan, D., Takawale, A., Lee, J., & Kassiri, Z. (2012). Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenes. Tissue Repair, 5(1), 1–13. https://doi.org/10.1186/1755-1536-5-15 - DOI
    1. Ferreira, A. M., Gentile, P., Chiono, V., & Ciardelli, G. (2012). Collagen for bone tissue regeneration. Acta Biomaterialia, 8(9), 3191–3200. https://doi.org/10.1016/j.actbio.2012.06.014 - DOI - PubMed
    1. Brinckmann, J. (2005). Collagens at a glance. Topics in Current Chemistry, 247, 1–6. https://doi.org/10.1007/b103817 - DOI
    1. de AzevedoGonçalvesMota, R. C., da Silva, E. O., de Lima, F. F., de Menezes, L. R., & Thiele, A. C. S. (2016). 3D printed scaffolds as a new perspective for bone tissue regeneration: Literature review. Materials Sciences and Applications, 07(08), 430–452. https://doi.org/10.4236/msa.2016.78039 - DOI

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