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Comment
. 2023 Jan 17;4(1):100907.
doi: 10.1016/j.xcrm.2022.100907.

Antiviral immunity rewired for axon regeneration

Meng Jiang  1 , Wenwen Zeng  2
Affiliations
Comment

Antiviral immunity rewired for axon regeneration

Meng Jiang et al. Cell Rep Med. .

Abstract

In Neuron's January 18th issue, Wang et al.1 report that activating the immune signaling IFNγ-cGAS-STING axis promotes axon regeneration in both the peripheral and central nervous systems. Their findings uncover the coordination mechanism of neural innate immune responses for axon regeneration.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1
Activating the immune signaling IFNγ-cGAS-STING axis promotes axon regeneration in both the PNS and the CNS Post nerve injury of DRG neuron, IFNγ is locally produced within the axons and acts on the Schwann cells and blood cells in the injury zone via its receptor complex IFNGR1/2, leading to upregulation of ISGs. cGAS is thereby induced in the non-neuronal cells and generates cGAMP to activate neuronal STING in trans, which then initiates the transcription of RAGs to promote axon regeneration. In the RGC neurons, IFNγ combined with Ptpn2 ablation can activate the IFNγ-cGAS-STING pathway and boost axon regeneration.
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References

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