Proteome-based insights for IDH-mutant glioma classification
- PMID: 36652918
- PMCID: PMC9873937
- DOI: 10.1016/j.xcrm.2022.100909
Proteome-based insights for IDH-mutant glioma classification
Abstract
In this issue, Bader et al.1 characterize the proteomes of diffuse glioma brain tumors by liquid chromatography mass spectrometry and classify isocitrate dehydrogenase (IDH)-mutant gliomas into two subtypes, which differ in oncogenic pathways and aerobic/anaerobic energy metabolism.
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status.Cell Rep Med. 2023 Jan 17;4(1):100877. doi: 10.1016/j.xcrm.2022.100877. Epub 2022 Dec 29. Cell Rep Med. 2023. PMID: 36584682 Free PMC article.
References
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- Leu S., von Felten S., Frank S., Vassella E., Vajtai I., Taylor E., Schulz M., Hutter G., Hench J., Schucht P., et al. IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival. Neuro Oncol. 2013;15:469–479. doi: 10.1093/neuonc/nos317. - DOI - PMC - PubMed
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