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Editorial
. 2023 Jan 24;81(3):235-236.
doi: 10.1016/j.jacc.2022.11.014.

PCSK9: The Nexus of Lipoprotein Metabolism and Inflammation in COVID-19

Affiliations
Editorial

PCSK9: The Nexus of Lipoprotein Metabolism and Inflammation in COVID-19

Sascha N Goonewardena et al. J Am Coll Cardiol. .
No abstract available

Keywords: COVID-19; PCSK9; inflammation; lipoprotein.

PubMed Disclaimer

Conflict of interest statement

Funding Support and Author Disclosures Dr Rosenson receives research funding to his institution from Amgen, Arrowhead, Eli Lilly, Novartis, and Regeneron; has received consulting fees from Amgen, Arrowhead, CRISPR Therapeutics, Eli Lilly, Lipigon, Novartis, Precision Biosciences, Regeneron, Ultrgenyx, and Verve; has received nonpromotional speaking fees from Amgen, Kowa, and Regeneron; has received royalties from Wolters Kluwer (UpToDate); and has stock holdings in MediMergent. Dr Goonewardena has reported that he has no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract

Comment on

  • PCSK9 Inhibition During the Inflammatory Stage of SARS-CoV-2 Infection.
    Navarese EP, Podhajski P, Gurbel PA, Grzelakowska K, Ruscio E, Tantry U, Magielski P, Kubica A, Niezgoda P, Adamski P, Junik R, Przybylski G, Pilaczyńska-Cemel M, Rupji M, Specchia G, Pinkas J, Gajda R, Gorog DA, Andreotti F, Kubica J. Navarese EP, et al. J Am Coll Cardiol. 2023 Jan 24;81(3):224-234. doi: 10.1016/j.jacc.2022.10.030. J Am Coll Cardiol. 2023. PMID: 36653090 Free PMC article. Clinical Trial.

References

    1. Choi D., Chen Q., Goonewardena S.N., et al. Efficacy of statin therapy in patients with hospital admission for COVID-19. Cardiovasc Drugs Ther. 2022;36:1165–1173. - PMC - PubMed
    1. Zhang X.J., Qin J.J., Cheng X., et al. In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19. Cell Metab. 2020;32:176–187.e4. - PMC - PubMed
    1. Talasaz A.H., Sadeghipour P., Aghakouchakzadeh M., et al. Investigating lipid-modulating agents for prevention or treatment of COVID-19: JACC state-of-the-art review. J Am Coll Cardiol. 2021;78:1635–1654. - PMC - PubMed
    1. Horton J.D., Cohen J.C., Hobbs H.H. PCSK9: a convertase that coordinates LDL catabolism. J Lipid Res. 2009;50(suppl):S172–177. - PMC - PubMed
    1. Lakoski S.G., Lagace T.A., Cohen J.C., Horton J.D., Hobbs H.H. Genetic and metabolic determinants of plasma PCSK9 levels. J Clin Endocrinol Metab. 2009;94:2537–2543. - PMC - PubMed