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. 2023 Mar 1;85(3):296-300.
doi: 10.1292/jvms.22-0416. Epub 2023 Jan 17.

Distribution of enrofloxacin within the bronchoalveolar region of healthy pigs

Moe Ijiri  1 , Shingo Ishikawa  1   2   3 , Seiji Hobo  1   2
Affiliations

Distribution of enrofloxacin within the bronchoalveolar region of healthy pigs

Moe Ijiri et al. J Vet Med Sci. .

Abstract

This study aimed to elucidate the distribution of enrofloxacin (ERFX) within the bronchoalveolar region of pigs. Six clinically healthy pigs were allocated to intramuscular treatments with either a single dose of 5 mg/kg or 7.5 mg/kg ERFX. Samples of plasma and bronchoalveolar lavage fluid (BALF) were obtained from each pig 0 (before administration), 3, 8, and 24 hr after ERFX administration. The ERFX concentrations in pulmonary epithelial lining fluid (ELF) and BALF cells showed a similar pattern during the experimental period, whereby ERFX concentrations in both ELF and BALF cells were higher than those in the plasma. These results suggest that intramuscularly injected ERFX is well-distributed in the bronchoalveolar region.

Keywords: bronchoalveolar lavage fluid; distribution; enrofloxacin; pig.

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Conflict of interest statement

The authors have no conflict of interest to declare. This study was supported by grants from the Bayer Yakuhin Ltd (Elanco Japan K.K.).

Figures

Fig. 1.
Fig. 1.
Concentration of enrofloxacin determined within plasma, pulmonary epithelial lining fluid (ELF), and cells in bronchoalveolar lavage fluid (BALF cells) after intramuscular injection for pigs. (A) Baytril 10% injectable solution (Dose: 5 mg/kg) (B) Baytril 1ject (Dose: 7.5 mg/kg). Data are shown as mean ± SD. Values with different letters indicate significant differences between regions at the same sampling time (P<0.05).
See this image and copyright information in PMC

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