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. 2023 Jan 19;404(5):513-520.
doi: 10.1515/hsz-2022-0286. Print 2023 Apr 25.

Neprilysin 4: an essential peptidase with multifaceted physiological relevance

Annika Buhr  1 , Ronja Schiemann  1 , Heiko Meyer  1   2
Affiliations

Neprilysin 4: an essential peptidase with multifaceted physiological relevance

Annika Buhr et al. Biol Chem. .

Abstract

Neprilysins are highly conserved ectoenzymes that hydrolyze and thus inactivate signaling peptides in the extracellular space. Herein, we focus on Neprilysin 4 from Drosophila melanogaster and evaluate the existing knowledge on the physiological relevance of the peptidase. Particular attention is paid to the role of the neprilysin in regulating feeding behavior and the expression of insulin-like peptides in the central nervous system. In addition, we assess the function of the peptidase in controlling the activity of the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase in myocytes, as well as the underlying molecular mechanism in detail.

Keywords: Drosophila melanogaster; SERCA; heart function; insulin signaling; metalloendopeptidase; peptide signaling.

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