Novel Polygenic Risk Score for Intracranial Aneurysms

Simon Frerich^{1

2}, John W Cole^{3

4}

Affiliations

¹ Institute for Stroke and Dementia Research, University Hospital (S.F.), LMU Munich, Germany.
² Graduate School of Systemic Neurosciences (GSN) (S.F.), LMU Munich, Germany.
³ Department of Neurology, Maryland Stroke Center, Baltimore (J.W.C.).
⁴ Baltimore VA Medical Center and University of Maryland School of Medicine (J.W.C.).

Editorial

Simon Frerich et al. Stroke. 2023 Mar.

. 2023 Mar;54(3):819-820.

doi: 10.1161/STROKEAHA.122.041807. Epub 2023 Jan 19.

Simon Frerich^{1

2}, John W Cole^{3

4}

¹ Institute for Stroke and Dementia Research, University Hospital (S.F.), LMU Munich, Germany.
² Graduate School of Systemic Neurosciences (GSN) (S.F.), LMU Munich, Germany.
³ Department of Neurology, Maryland Stroke Center, Baltimore (J.W.C.).
⁴ Baltimore VA Medical Center and University of Maryland School of Medicine (J.W.C.).

No abstract available

Keywords: Editorials; intracranial aneurysms.

Comment on

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.
Bakker MK, Kanning JP, Abraham G, Martinsen AE, Winsvold BS, Zwart JA, Bourcier R, Sawada T, Koido M, Kamatani Y, Morel S, Amouyel P, Debette S, Bijlenga P, Berrandou T, Ganesh SK, Bouatia-Naji N, Jones G, Bown M, Rinkel GJE, Veldink JH, Ruigrok YM; HUNT All-In Stroke, CADISP group, International Consortium for Blood Pressure, International Headache Genetics Consortium, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group. Bakker MK, et al. Stroke. 2023 Mar;54(3):810-818. doi: 10.1161/STROKEAHA.122.040715. Epub 2023 Jan 19. Stroke. 2023. PMID: 36655558 Free PMC article.

1. Bell J. Predicting disease using genomics. Nature. 2004;429:453–456. - PubMed
1. Janssens ACJ. Validity of polygenic risk scores: are we measuring what we think we are? Human Molecular Genetics. 2019;28:R143–R150. - PMC - PubMed
1. Lewis CM, Vassos E. Polygenic risk scores: from research tools to clinical instruments. Genome Med. 2020;12:44. - PMC - PubMed
1. Bakker MK, Ruigrok YM. Genetics of Intracranial Aneurysms. Stroke. 2021;52:3004–3012. - PubMed
1. Kleinloog R, van ‘t Hof FNG, Wolters FJ, Rasing I, van der Schaaf IC, Rinkel GJE, Ruigrok YM. The Association Between Genetic Risk Factors and the Size of Intracranial Aneurysms at Time of Rupture. Neurosurgery. 2013;73:705–708. - PubMed