Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 6;222(2):e202301035.
doi: 10.1083/jcb.202301035. Epub 2023 Jan 19.

Mammalian fertilization: Does sperm IZUMO1 mediate fusion as well as adhesion?

Enrica Bianchi  1 , Gavin J Wright  1
Affiliations

Mammalian fertilization: Does sperm IZUMO1 mediate fusion as well as adhesion?

Enrica Bianchi et al. J Cell Biol. .

Abstract

The molecular mechanism of sperm-egg fusion is a long-standing mystery in reproduction. Brukman and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202207147) now provide evidence that the sperm surface protein IZUMO1, which is essential for mammalian fertilization, can induce membrane fusion in cultured cells.

PubMed Disclaimer

Comment on

References

    1. Bianchi, E., and Wright G.J.. 2016. Annu. Rev. Genet. 10.1146/annurev-genet-121415-121834 - DOI - PubMed
    1. Inoue, N., et al. 2005. Nature. 10.1038/nature03362 - DOI
    1. Okabe, M. 2015. Asian J. Androl. 10.4103/1008-682X.153299 - DOI - PMC - PubMed
    1. Hernández, J.M., and Podbilewicz B.. 2017. Development. 10.1242/dev.155523 - DOI
    1. Wright, G.J., and Bianchi E.. 2016. Cell Tissue Res. 10.1007/s00441-015-2243-3 - DOI - PMC - PubMed