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Comment
. 2023 Jan 18;111(2):142-144.
doi: 10.1016/j.neuron.2022.12.032.

ApoE4 makes microglia trem2bling

Michael T Heneka  1
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ApoE4 makes microglia trem2bling

Michael T Heneka. Neuron. .
Free article

Abstract

The ApoE-Trem2 pathway links two of the most important genetic risk variants for sporadic Alzheimer's disease. In this issue of Neuron, Gratuze and colleagues1 report that Trem2 deficiency further aggravates neurodegeneration in tau mutant mice expressing human ApoE4. Together with previous work, this study points to a complex interaction and highlights the need for studying molecular interactions on all human ApoE variants.

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Conflict of interest statement

Declaration of interests M.T.H. is a science advisory board member for IFM Therapeutics, Alector Inc., Cyclerion Inc., and Muna Therapeutics. He has received honoraria for oral presentations from Biogen, Takeda, NovoNordisk, and AD Immune.

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