miR-124-3p mediates polygenic risk shared between schizophrenia and bipolar disorder
- PMID: 36657396
- DOI: 10.1016/j.neuron.2022.12.024
miR-124-3p mediates polygenic risk shared between schizophrenia and bipolar disorder
Abstract
In this issue of Neuron, Namkung et al. demonstrate that the microRNA miR-124-3p is associated with polygenic risk scores shared between schizophrenia and bipolar disorder and confers risk to behavioral alterations common to these two disorders through modulation of AMPA receptor neurotransmission.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder.Neuron. 2023 Jan 18;111(2):220-235.e9. doi: 10.1016/j.neuron.2022.10.031. Epub 2022 Nov 14. Neuron. 2023. PMID: 36379214 Free PMC article.
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