Oncogenic role for an EWS-FLI1 suppressor

Affiliations

¹ Seattle Children's Research Institute, Seattle, WA, USA.
² Seattle Children's Research Institute, Seattle, WA, USA. beth.lawlor@seattlechildrens.org.

Comment

April A Apfelbaum et al. Nat Cell Biol. 2023 Feb.

. 2023 Feb;25(2):214-216.

doi: 10.1038/s41556-022-01067-8.

¹ Seattle Children's Research Institute, Seattle, WA, USA.
² Seattle Children's Research Institute, Seattle, WA, USA. beth.lawlor@seattlechildrens.org.

No abstract available

Comment on

ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation.
Gao Y, He XY, Wu XS, Huang YH, Toneyan S, Ha T, Ipsaro JJ, Koo PK, Joshua-Tor L, Bailey KM, Egeblad M, Vakoc CR. Gao Y, et al. Nat Cell Biol. 2023 Feb;25(2):298-308. doi: 10.1038/s41556-022-01060-1. Epub 2023 Jan 19. Nat Cell Biol. 2023. PMID: 36658219 Free PMC article.
The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma.
Lu DY, Ellegast JM, Ross KN, Malone CF, Lin S, Mabe NW, Dharia NV, Meyer A, Conway A, Su AH, Selich-Anderson J, Taslim C, Byrum AK, Seong BKA, Adane B, Gray NS, Rivera MN, Lessnick SL, Stegmaier K. Lu DY, et al. Nat Cell Biol. 2023 Feb;25(2):285-297. doi: 10.1038/s41556-022-01059-8. Epub 2023 Jan 19. Nat Cell Biol. 2023. PMID: 36658220 Free PMC article.

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