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Review
. 2023 Jan 20;38(1):45.
doi: 10.1007/s10103-022-03704-y.

An update on fractional picosecond laser treatment: histology and clinical applications

Yanjun Zhou  1   2 , Michael R Hamblin  3 , Xiang Wen  4   5
Affiliations
Review

An update on fractional picosecond laser treatment: histology and clinical applications

Yanjun Zhou et al. Lasers Med Sci. .

Abstract

Picosecond lasers have a very short pulse duration and a high peak power density. When fractional optical delivery systems are attached to picosecond lasers, they generate an array of concentrated microspots with a high fluence surrounded by areas with a low fluence. This article discusses the histologic characteristics and clinical applications of fractional picosecond laser treatment. Fractional picosecond laser produces laser-induced optical breakdown (LIOB) and laser-induced cavitation (LIC) in the epidermis and dermis respectively, and can encourage skin regeneration and dermal remodeling. It has been shown that fractional picosecond laser has a positive effect on facial photoaging, enlarged facial pores, dyspigmentation, wrinkles, and atrophic scars. Further research is still needed to confirm the benefits of fractional picosecond lasers.

Keywords: Clinical applications; Fractional optical delivery systems; Histologic characteristics; Picosecond laser.

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Conflict of interest statement

MRH declares the following potential conflicts of interest. Scientific Advisory Boards: Transdermal Cap Inc, Cleveland, OH; Hologenix Inc. Santa Monica, CA; Vielight, Toronto, Canada; JOOVV Inc, Minneapolis-St. Paul MN; Sunlighten, Kansas City, MO; Consulting; USHIO Corp, Japan; Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany; Klox Asia, Guangzhou, China. Stockholding: Niraxx Light Therapeutics, Inc., Irvine CA; JelikaLite Corp, New York NY. All other authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A Photo of a patient with facial photoaging; b 7 months after one fractional picosecond laser treatment (wavelength 755 nm, focus mode, energy 0.71 J/cm2, frequency 10 Hz, spot size 6 mm)
Fig. 2
Fig. 2
A Photo of a patient with enlarged facial pores; b 2 months after one fractional picosecond laser treatment (wavelength 755 nm, energy 0.4 J/cm.2, frequency 5 Hz, spot size 8 mm)
See this image and copyright information in PMC

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