Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan 20;23(1):28.
doi: 10.1186/s12905-023-02166-w.

Human papilloma virus infection and its associated risk for cervical lesions: a cross-sectional study in Putuo area of Shanghai, China

Haiping Luan  1
Affiliations

Human papilloma virus infection and its associated risk for cervical lesions: a cross-sectional study in Putuo area of Shanghai, China

Haiping Luan. BMC Womens Health. .

Abstract

Objective: To investigate the human papilloma virus (HPV) infection status, main subtypes and age distribution characteristics of women in the Putuo area of Shanghai.

Methods: A total of 13,936 subjects were enrolled in this study. These subjects were 15-89 years old, with a mean age of 41.68. Real-time fluorescence quantitative polymerase chain reaction technology was used to detect 21 types of HPV.

Results: A total of 2,500 subjects with HPV infections were detected in 13,936 cervical exfoliated cell specimens (total infection rate 17.9%). There were 15 people aged below 20,486 people aged 21-30,876 people aged 31-40,484 people aged 41-50, 338 people aged 51-60, and 301 people aged > 60. In total, 1,893 (75.7%) subjects had a single type of HPV infection, 424 (16.9%) had a double infection, and 183 had triple or more infections (7.4%). The top 6 subtypes of HPV infection in the Shanghai Putuo District were HPV 52 (3.81%), HPV 58 (2.46%), HPV 16 (2.43%), HPV 53 (2.30%), HPV 81 (1.74%) and HPV 39 (1.5%). The number of high-risk HPV infections was 1,978, and the total infection rate was 14.19%. The number of intermediate-risk HPV infections was 578, and the total infection rate was 4.15%. The number of low-risk HPV infections was 338, and the total infection rate was 2.43%.

Conclusion: The top 3 populations with HPV infection rates in the Putuo District, Shanghai, were ≤ 20 years old, older than 60, and 21-30 years old. The infection rate of HPV in cervical outpatient clinics was significantly higher than that of other departments. The 9-valent vaccine is recommended for HPV vaccination in this area.

Keywords: Cervical cancer; HPV; Screening.

PubMed Disclaimer

Conflict of interest statement

All of the authors had no any personal, financial, commercial, or academic conflicts of interest separately.

Figures

Fig. 1
Fig. 1
Distribution of several heavy infections among 2500 HPV infections
Fig. 2
Fig. 2
Distribution of different departments in 2500 cases of HPV infection
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Xi LF, Schiffman M, Ke Y, Hughes JP, Galloway DA, He Z, et al. Type-dependent association between risk of cervical intraepithelial neoplasia and viral load of oncogenic human papillomavirus types other than types 16 and 18. Int J Cancer. 2017;140(8):1747–1756. doi: 10.1002/ijc.30594. - DOI - PMC - PubMed
    1. Jin R, Li HF. The effect of persistent high-risk HPV infection on the progression of cervical precancerous lesions. Matern Child Health Care China. 2020;35(3):406–409. doi: 10.19829/j.zgfybj-issn.1001-4411.2020.03.006. - DOI
    1. Gupta G, Giannino V, Rishi N, Glueck R. Immunogenicity of next-generation HPV vaccines in non-human primates: measles-vectored HPV vaccine versus Pichia pastoris recombinant protein vaccine. Vaccine. 2016;34(39):4724–4731. doi: 10.1016/j.vaccine.2016.07.051. - DOI - PMC - PubMed
    1. Ward JM, Schmalenberg K, Antonishyn NA, Hambleton IR, Blackman EL, Levett PN, et al. Human papillomavirus genotype distribution in cervical samples among vaccine naïve Barbados women. Cancer Causes Control. 2017;28(11):1323–1332. doi: 10.1007/s10552-017-0959-y. - DOI - PubMed
    1. Asciutto KC, Henningsson AJ, Borgfeldt H, Darlin L, Borgfeldt C. Vaginal and urine self-sampling compared to cervical sampling for HPV-testing with the cobas 4800 HPV test. Anticancer Res. 2017;37(8):4183–4187. doi: 10.21873/anticanres.11807. - DOI - PubMed

Supplementary concepts