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Review
. 2023 Jan 20;21(1):16.
doi: 10.1186/s12957-023-02901-5.

The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis

Yu-Shi Dai  1 , Hai-Jie Hu  1 , Tian-Run Lv  1 , Ya-Fei Hu  1 , Rui-Qi Zou  1 , Fu-Yu Li  2
Affiliations
Review

The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis

Yu-Shi Dai et al. World J Surg Oncol. .

Abstract

Background: Some studies have pointed out that a wide resection margin can improve the prognosis of intrahepatic cholangiocarcinoma, but some researchers disagree and believe that a wide margin may increase complications. The optimal margin length of intrahepatic cholangiocarcinoma is controversial.

Method: The literature was searched in PubMed, MedLine, Embase, the Cochrane Library, and Web of Science until December 31, 2021, to evaluate the postoperative outcomes of patients with different margin width after resection. Odds ratios (ORs) with 95% confidence intervals were used to determine the effect size.

Result: A total of 11 articles were included in this meta-analysis, including 3007 patients. The narrow group had significantly lower 1-, 3-, and 5-year overall survival rates and recurrence-free survival rates than the wide group. Postoperative morbidity and prognostic factors were also evaluated.

Conclusion: A resection margin width of over 10 mm is recommended in intrahepatic cholangiocarcinoma patients, especially in patients with negative lymph node and early tumor stage. When the resection margin width cannot be greater than 10 mm, we should ensure that the resection margin width is greater than 5 mm.

Keywords: Intrahepatic cholangiocarcinoma; Prognosis; Resection; Survival.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flowchart of the study selection
Fig. 2
Fig. 2
The a 1-, b 3-, and c 5-year overall survival (OS) rates and the d 1-, e 3-, and f 5-year recurrence-free survival (RFS) of the <10-mm margin group vs. the ≥10-mm margin group
Fig. 3
Fig. 3
a–c 1-, 3-, and 5-year overall survival (OS) rates of the <5-mm margin group vs. the ≥5-mm margin group and d–f the 5–9-mm margin group vs. the ≥10-mm margin group
See this image and copyright information in PMC

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