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Review
. 2023 Jan 20;22(1):8.
doi: 10.1186/s12937-022-00833-6.

The efficacy of vitamin D supplementation for irritable bowel syndrome: narrow scope and GRADE miss-interpretation

Affiliations
Review

The efficacy of vitamin D supplementation for irritable bowel syndrome: narrow scope and GRADE miss-interpretation

Mohamed Abuelazm et al. Nutr J. .

Abstract

We read the article by Haung et al. that pooled the effects of vitamin D on irritable bowel syndrome symptoms and associated quality of life. However, the current review suffers from some methodological errors: inadequate search strategy; the grading of recommendations assessment, development, and evaluation (GRADE) miss-assessment; and miss-interpretation. Accordingly, addressing the emphasized limitations will lead to more robust findings and conclusions.

Keywords: IBS; IBS-Qol; IBS-SSS; Irritable bowel syndrome; Vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Huang H, Lu L, Chen Y, Zeng Y, Xu C. The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis. Nutr J. 2022;21:1–11. doi: 10.1017/S0007114522003038. - DOI - PMC - PubMed
    1. Zeid W, Ezzeldeen E, Khattab M, Ahmed S, Abdo M. Effect of vitamin D3 (cholecalciferol) supplementation on gastrointestinal symptoms in patients with irritable bowel syndrome attending El-Mahsama Family Practice Center, Ismailia, Egypt: a randomized clinical trial. Al-Azhar Int Med J. 2020;0:0. doi: 10.21608/aimj.2020.32333.1254. - DOI
    1. Williams CE, Williams EA, Corfe BM. Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial. Eur J Nutr. 2022;61:299–308. doi: 10.1007/s00394-021-02633-w. - DOI - PMC - PubMed
    1. Jalili M, Vahedi H, Poustchi H, Hekmatdoost A. Effects of vitamin D supplementation in patients with irritable bowel syndrome: a randomized, double-blind, placebo-controlled clinical trial. Int J Prev Med. 2019;10:16. doi: 10.4103/ijpvm.IJPVM_512_17. - DOI - PMC - PubMed
    1. Abuelazm M, Muhammad S, Gamal M, Labieb F, Amin MA, Abdelazeem B, et al. The effect of vitamin D supplementation on the severity of symptoms and the quality of life in irritable bowel syndrome patients: a systematic review and meta-analysis of randomized controlled trials. Nutrients. 2022;14. - PMC - PubMed

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