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Review
. 2023 Jan 19;18(1):3.
doi: 10.1186/s13027-023-00480-4.

Emerging role of microbiota derived outer membrane vesicles to preventive, therapeutic and diagnostic proposes

Saba Jalalifar  1   2 , Hassan Morovati Khamsi  3 , Seyed Reza Hosseini-Fard  4 , Sajad Karampoor  5 , Bahar Bajelan  6 , Gholamreza Irajian  7   8 , Rasoul Mirzaei  9
Affiliations
Review

Emerging role of microbiota derived outer membrane vesicles to preventive, therapeutic and diagnostic proposes

Saba Jalalifar et al. Infect Agent Cancer. .

Erratum in

Abstract

The role of gut microbiota and its products in human health and disease is profoundly investigated. The communication between gut microbiota and the host involves a complicated network of signaling pathways via biologically active molecules generated by intestinal microbiota. Some of these molecules could be assembled within nanoparticles known as outer membrane vesicles (OMVs). Recent studies propose that OMVs play a critical role in shaping immune responses, including homeostasis and acute inflammatory responses. Moreover, these OMVs have an immense capacity to be applied in medical research, such as OMV-based vaccines and drug delivery. This review presents a comprehensive overview of emerging knowledge about biogenesis, the role, and application of these bacterial-derived OMVs, including OMV-based vaccines, OMV adjuvants characteristics, OMV vehicles (in conjugated vaccines), cancer immunotherapy, and drug carriers and delivery systems. Moreover, we also highlight the significance of the potential role of these OMVs in diagnosis and therapy.

Keywords: Adjuvant; Biomarker; Drug delivery; Microbiota; Outer membrane vesicle; Vaccine.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.

Figures

Fig. 1
Fig. 1
Biogenesis and cargo of outer membrane vesicles. It has been found that some components impact the OMV biogenesis including (1) Peptidoglycan endopeptidases, (2) cross-links of Meso-diaminopimelic acid– Meso-diaminopimelic acid within the peptidoglycan, (3) LPS or peptidoglycan fragments, (4) LPS-associated molecules, (5) insertion of PQS into the outer leaflet of the outer membrane, and (6) envelope components. OMV, outer membrane vesicle; LPS, lipopolysaccharide, PQS, Pseudomonas quinolone signal
Fig. 2
Fig. 2
Biomedical applications of outer-membrane vesicles. (1) Vaccine, (2) adjuvant, (3) cancer immunotherapy agent, (4) delivery vehicle, and (5) inhibiting bacterial adhesion
See this image and copyright information in PMC

References

    1. Mirzaei R, Afaghi A, Babakhani S, Sohrabi MR, Hosseini-Fard SR, Babolhavaeji K, Akbari SKA, Yousefimashouf R, Karampoor S. Role of microbiota-derived short-chain fatty acids in cancer development and prevention. Biomed Pharmacother. 2021;139:111619. doi: 10.1016/j.biopha.2021.111619. - DOI - PubMed
    1. Mirzaei R, Bouzari B, Hosseini-Fard SR, Mazaheri M, Ahmadyousefi Y, Abdi M, Jalalifar S, Karimitabar Z, Teimoori A, Keyvani H. Role of microbiota-derived short-chain fatty acids in nervous system disorders. Biomed Pharmacother. 2021;139:111661. doi: 10.1016/j.biopha.2021.111661. - DOI - PubMed
    1. Mirzaei R, Dehkhodaie E, Bouzari B, Rahimi M, Gholestani A, Hosseini-Fard SR, Keyvani H, Teimoori A, Karampoor S. Dual role of microbiota-derived short-chain fatty acids on host and pathogen. Biomed Pharmacother. 2021;145:112352. doi: 10.1016/j.biopha.2021.112352. - DOI - PubMed
    1. Ahmadi Badi S, Moshiri A, Fateh A, Rahimi Jamnani F, Sarshar M, Vaziri F, Siadat SD. Microbiota-derived extracellular vesicles as new systemic regulators. Front Microbiol. 2017;8:1610. doi: 10.3389/fmicb.2017.01610. - DOI - PMC - PubMed
    1. Mirzaei R, Mirzaei H, Alikhani MY, Sholeh M, Arabestani MR, Saidijam M, Karampoor S, Ahmadyousefi Y, Moghadam MS, Irajian GR. Bacterial biofilm in colorectal cancer: What is the real mechanism of action? Microb Pathog. 2020;142:104052. doi: 10.1016/j.micpath.2020.104052. - DOI - PubMed

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