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Review
. 2023 Jul-Aug;14(4):e1772.
doi: 10.1002/wrna.1772. Epub 2023 Jan 19.

RNA-binding proteins in autoimmunity: From genetics to molecular biology

Valeria Lodde  1 , Matteo Floris  1 , Enrico Zoroddu  1 , Ignazio Roberto Zarbo  2 , Maria Laura Idda  3
Affiliations
Review

RNA-binding proteins in autoimmunity: From genetics to molecular biology

Valeria Lodde et al. Wiley Interdiscip Rev RNA. 2023 Jul-Aug.

Abstract

Autoimmune diseases (ADs) are chronic pathologies generated by the loss of immune tolerance to the body's own cells and tissues. There is growing recognition that RNA-binding proteins (RBPs) critically govern immunity in healthy and pathological conditions by modulating gene expression post-transcriptionally at all levels: nuclear mRNA splicing and modification, export to the cytoplasm, as well as cytoplasmic mRNA transport, storage, editing, stability, and translation. Despite enormous efforts to identify new therapies for ADs, definitive solutions are not yet available in many instances. Recognizing that many ADs have a strong genetic component, we have explored connections between the molecular biology and the genetics of RBPs in ADs. Here, we review the genetics and molecular biology of RBPs in four major ADs, multiple sclerosis (MS), type 1 diabetes mellitus (T1D), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). We anticipate that gaining insights into the genetics and biology of ADs can facilitate the discovery of new therapies. This article is categorized under: RNA in Disease and Development > RNA in Disease.

Keywords: RBPs; autoimmune diseases; genetic variability; posttranscriptional; regulation.

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References

FURTHER READING
    1. Li Durose, W. W., Ito, J., Kakita, A., Iguchi, Y., Katsuno, M., Kunisawa, K., Shimizu, T., & Ikenaka, K. (2021). Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene. Journal of Neurochemistry, 157(6), 2070-2090. https://doi.org/10.1111/jnc.15190
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