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. 2023 Feb 1;24(12 Suppl 2):S76-S86.
doi: 10.1097/PCC.0000000000003160. Epub 2023 Jan 20.

Methodology of the Second Pediatric Acute Lung Injury Consensus Conference

Narayan Iyer  1 , Robinder Khemani  2 , Guillaume Emeriaud  3 , Yolanda M López-Fernández  4 , Steven Kwasi Korang  2   5 , Katherine M Steffen  6 , Ryan P Barbaro  7 , Melania M Bembea  8 ; Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) Group on behalf and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Collaborators, Affiliations

Methodology of the Second Pediatric Acute Lung Injury Consensus Conference

Narayan Iyer et al. Pediatr Crit Care Med. .

Abstract

Objectives: This article describes the methodology used for The Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2). The PALLIC-2 sought to develop evidence-based clinical recommendations and when evidence was lacking, expert-based consensus statements and research priorities for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS).

Data sources: Electronic searches were conducted using PubMed, Embase, and Cochrane Library (CENTRAL) databases from 2012 to March 2022.

Study selection: Content was divided into 11 sections related to PARDS, with abstract and full text screening followed by data extraction for studies which met inclusion with no exclusion criteria.

Data extraction: We used a standardized data extraction form to construct evidence tables, grade the evidence, and formulate recommendations or statements using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.

Data synthesis: This consensus conference was comprised of a multidisciplinary group of international experts in pediatric critical care, pulmonology, respiratory care, and implementation science which followed standards set by the Institute of Medicine, using the GRADE system and Research And Development/University of California, Los Angeles appropriateness method, modeled after PALICC 2015. The panel of 52 content and four methodology experts had several web-based meetings over the course of 2 years. We conducted seven systematic reviews and four scoping reviews to cover the 11 topic areas. Dissemination was via primary publication listing all statements and separate supplemental publications for each subtopic that include supporting arguments for each recommendation and statement.

Conclusions: A consensus conference of experts from around the world developed recommendations and consensus statements for the definition and management of PARDS and identified evidence gaps which need further research.

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Conflict of interest statement

Dr. Emeriaud’s institution received funding from Fonds de Recherche du Québec - Santé and MAquet. Dr. Barbaro’s institution received funding from the National Institutes of Health (NIH) (R01HL153519); he disclosed that he is the Extracorporeal Life Support Organization Registry Chair. Dr. Bembea’s institution received funding from the National Institute of Neurological Disorders and Stroke, the National Institute of Child Health and Human Development, and a Grifols Investigator Sponsored Research Grant. Drs. Barbaro and Bembea received support for article research from the NIH. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Figures

Figure 1.
Figure 1.
Timeline and overview of the updated international guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2) RAND/UCLA= Research And Development/University of California, Los Angeles
Figure 2.
Figure 2.
PALICC-2 recommendation flowsheet *CoE: Certainty of evidence **EtD: Evidence to decision framework
See this image and copyright information in PMC

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