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. 2022 Dec 21;8(1):2.
doi: 10.3390/tropicalmed8010002.

First Case of Monkeypox in Venezuela: Partial Complete Genome Sequence Allowed Its Grouping into the West African Clade II

Pierina D'Angelo  1 , Carmen L Loureiro  2 , Rossana C Jaspe  2 , Yoneira F Sulbaran  2 , Lieska Rodríguez  1 , Víctor Alarcón  1 , José Manuel García  3 , José Luis Zambrano  4 , Ferdinando Liprandi  5 , Héctor R Rangel  2 , Flor H Pujol  2
Affiliations

First Case of Monkeypox in Venezuela: Partial Complete Genome Sequence Allowed Its Grouping into the West African Clade II

Pierina D'Angelo et al. Trop Med Infect Dis. .

Abstract

The ongoing epidemic of monkeypox virus (MPXV) infection has already reached more than 50,000 persons worldwide until the end of August 2022. We report the first case detected in Venezuela. The patient reported traveling from Spain and contact with friends tested positive for MPXV after his return. Partial complete genome phylogenetic analysis allowed to group the isolate within the clade II of MPXV, the major one circulating worldwide. No other case of MPXV has been detected until the end of August 2022 in the country, although the presence of undiagnosed cases due to the fear of stigmatization cannot be ruled out.

Keywords: West African clade; clade II; international outbreak; monkeypox; phylogenetic analysis.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Algorithm from Venezuelan INHRR for the molecular detection of MPXV cases. Samples from patients with history of international travel were directly tested for the presence of MPXV DNA.
Figure 2
Figure 2
Phylogenetic analysis of the first case pf MPXV in Venezuela. The different lineages described for clade IIb are shown.
See this image and copyright information in PMC

References

    1. WHO Director-General Declares the Ongoing Monkeypox Outbreak a Public Health Emergency of International Concern. [(accessed on 25 August 2022)]. Available online: https://www.who.int/europe/news/item/23-07-2022-who-director-general-dec....
    1. Zhu M., Ji J., Shi D., Lu X., Wang B., Wu N., Wu J., Yao H., Li L. Unusual Global Outbreak of Monkeypox: What Should We Do? Front. Med. 2022;16:507–517. doi: 10.1007/s11684-022-0952-z. - DOI - PMC - PubMed
    1. Mathieu E., Spooner F., Dattani S., Ritchie H., Roser M. Mpox (monkeypox). Our World in Data. 2022. [(accessed on 8 August 2022)]. Available online: https://ourworldindata.org/monkeypox.
    1. Prier J.E., Sauer R.M. A Pox Disease of Monkeys. Ann. N. Y. Acad. Sci. 1960;85:951–959. doi: 10.1111/j.1749-6632.1960.tb50015.x. - DOI - PubMed
    1. de Sousa Á.F.L., de Sousa A.R., Fronteira I. Monkeypox: Between Precision Public Health and Stigma Risk. Rev. Bras. Enferm. 2022;75:e750501. doi: 10.1590/0034-7167.2022750501. - DOI - PubMed

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