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. 2022 Dec 27;8(1):21.
doi: 10.3390/tropicalmed8010021.

No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda

Arthur W D Edridge  1   2 , Nathalie van den Brekel  1 , Philly Mukungu  3 , Rachael Nakayima  3 , Samuel Bbosa  3 , Peter Isagara  3 , Michael van Boele Hensbroek  1 , Lia van der Hoek  2 , John Kayiwa  4 , Julius J Lutwama  4 , Richard Idro  5
Affiliations

No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda

Arthur W D Edridge et al. Trop Med Infect Dis. .

Abstract

We investigated whether Ntwetwe virus-a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy-was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case-control was conducted between September 2019 and September 2020, including cases with severe neurological disease and mild febrile illness, matched to a healthy control without fever. Among 143 subjects, no cases with an acute infection were identified. This result suggests that Ntwetwe virus does not cause a major burden of disease amongst children presenting to Kiboga hospital during the study period.

Keywords: CNS infection; Uganda; emerging infectious diseases; orthobunyavirus; pediatrics; virus discovery.

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Conflict of interest statement

The authors declare no conflict of interest.

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