Pharmacological management of disease by overcoming structural adversity
- PMID: 36669468
- DOI: 10.1016/j.chembiol.2022.12.008
Pharmacological management of disease by overcoming structural adversity
Abstract
In this issue of Cell Chemical Biology, Sun et al. utilize computational and protein expression analyses, plus pharmacological proteostasis network activation, to simultaneously correct two genetic diseases linked to a single protein rather than modify the responsible DNA.
Copyright © 2022 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis.Cell Chem Biol. 2023 Jan 19;30(1):22-42.e5. doi: 10.1016/j.chembiol.2022.12.004. Epub 2023 Jan 10. Cell Chem Biol. 2023. PMID: 36630963 Free PMC article.
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