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Comment
. 2023 Jan 19;186(2):233-235.
doi: 10.1016/j.cell.2022.12.040.

Is aging a "Retro"spective event?

Nirmalya Dasgupta  1 , Peter D Adams  2
Affiliations
Free article
Comment

Is aging a "Retro"spective event?

Nirmalya Dasgupta et al. Cell. .
Free article

Abstract

Reactivation of endogenous retroviruses (ERVs), the relics of ancient infections, has been implicated in a number of disease contexts. In this issue of Cell, Liu et al. show how reactivation of ERVs in old age can induce senescence. This awakening of ERVs is associated with their epigenetic derepression and contributes to age-associated chronic inflammation.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Resurrection of endogenous retroviruses during aging reinforces senescence.
    Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C, Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Liu X, et al. Cell. 2023 Jan 19;186(2):287-304.e26. doi: 10.1016/j.cell.2022.12.017. Epub 2023 Jan 6. Cell. 2023. PMID: 36610399

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