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Comment
. 2023 Jan 19;186(2):235-237.
doi: 10.1016/j.cell.2022.12.015.

Coordinated cancer chaos

Hendrik A Messal  1 , Jacco van Rheenen  2
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Coordinated cancer chaos

Hendrik A Messal et al. Cell. .
Free article

Abstract

Stochastic processes, such as genetic instability and microenvironment evolution, drive tumor heterogeneity, thereby creating the chaotic appearance of tumors in histopathology. In this issue of Cell, Lin et al. reveal that tumors are surprisingly spatially organized from a molecular to tissue scale, indicating that cancers evolve as autonomously patterned systems.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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