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Comment
. 2023 Jan 19;83(2):163-164.
doi: 10.1016/j.molcel.2022.12.028.

SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease

Carol C L Chen  1 , Augusto Faria Andrade  1 , Nada Jabado  2
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Free article
Comment

SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease

Carol C L Chen et al. Mol Cell. .
Free article

Abstract

To investigate epigenetic dependencies and identify therapeutic vulnerabilities, Mo et al.1 and Panditharatna et al.2 performed CRISPR screens and show that deadly H3K27M gliomas are dependent on mammalian BAF (SWI/SNF) chromatin remodeling complex.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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