Corrigendum to "An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication" [Genomics Proteomics Bioinformatics19 (1) (2021) 108-122]

Guang Song¹, Emily M Lee², Jianbo Pan³, Miao Xu⁴, Hee-Sool Rho¹, Yichen Cheng², Nadia Whitt⁵, Shu Yang⁵, Jennifer Kouznetsova⁵, Carleen Klumpp-Thomas⁵, Samuel G Michael⁵, Cedric Moore¹, Ki-Jun Yoon⁶, Kimberly M Christian⁷, Anton Simeonov⁵, Wenwei Huang⁵, Menghang Xia⁵, Ruili Huang⁵, Madhu Lal-Nag⁸, Hengli Tang⁹, Wei Zheng¹⁰, Jiang Qian¹¹, Hongjun Song¹², Guo-Li Ming¹³, Heng Zhu¹⁴

Affiliations

¹ Department of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
² Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
³ Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
⁴ National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA; Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
⁵ National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
⁶ Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁷ Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁸ National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: Madhu.Lal@nih.gov.
⁹ Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. Electronic address: tang@bio.fsu.edu.
¹⁰ National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: wzheng@mail.nih.gov.
¹¹ Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: jiang.qian@jhmi.edu.
¹² Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: shongjun@pennmedicine.upenn.edu.
¹³ Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: gming@pennmedicine.upenn.edu.
¹⁴ Department of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: hzhu4@jhmi.edu.

PMID: 36669818
PMCID: PMC9880883
DOI: 10.1016/j.gpb.2022.12.009

Published Erratum

Corrigendum to "An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication" [Genomics Proteomics Bioinformatics19 (1) (2021) 108-122]

Guang Song et al. Genomics Proteomics Bioinformatics. 2022 Aug.

. 2022 Aug;20(4):808-809.

doi: 10.1016/j.gpb.2022.12.009.

Authors

Affiliations

¹ Department of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
² Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
³ Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
⁴ National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA; Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
⁵ National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
⁶ Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁷ Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁸ National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: Madhu.Lal@nih.gov.
⁹ Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. Electronic address: tang@bio.fsu.edu.
¹⁰ National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: wzheng@mail.nih.gov.
¹¹ Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: jiang.qian@jhmi.edu.
¹² Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: shongjun@pennmedicine.upenn.edu.
¹³ Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: gming@pennmedicine.upenn.edu.
¹⁴ Department of Pharmacology & Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: hzhu4@jhmi.edu.

PMID: 36669818
PMCID: PMC9880883
DOI: 10.1016/j.gpb.2022.12.009

No abstract available

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Figures

**Figure 6**
**Experimental validation of the proteasome inhibitors** A. PPI network analysis of virus proteins and human proteasome subunits reveals that most of the interacting proteasome subunits are part of the 20S core particle. B. Percentage of the ZIKV-binding subunits in 26S proteasome and its two sub-complexes, the 20S core particle and the 19S regulatory particle. C. Inhibition of ZIKV expression in human glioblastoma cell line SNB-19 by a panel of proteasome inhibitors. The SNB-19 cells were infected by ZIKV PRVABC59 (MOI = 1) in the presence of 1 µM of each inhibitor and then incubated for 48 h before the cultures were analyzed for ZIKV-E protein expression by immunostaining. Mock indicates cells without ZIKV infection. Scale bar: 100 µm. D. and E. Sample images (D) and quantification (E) of titer assay to assess the potency of the proteasome inhibitors against infectious ZIKV production in SNB-19 cells. All data were normalized to that of 0 µM for each compound. Dose-dependent antiviral activity is presented as fluorescent focus-forming units per ml (FFU/ml) and data are represented as mean ± SD (n = 6). Curves represent best fits for calculating IC₅₀ values (listed to the right). MOI, multiplicity of infection; ZIKV-E, ZIKV envelope.

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Erratum for

An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication.
Song G, Lee EM, Pan J, Xu M, Rho HS, Cheng Y, Whitt N, Yang S, Kouznetsova J, Klumpp-Thomas C, Michael SG, Moore C, Yoon KJ, Christian KM, Simeonov A, Huang W, Xia M, Huang R, Lal-Nag M, Tang H, Zheng W, Qian J, Song H, Ming GL, Zhu H. Song G, et al. Genomics Proteomics Bioinformatics. 2021 Feb;19(1):108-122. doi: 10.1016/j.gpb.2020.06.016. Epub 2021 Feb 19. Genomics Proteomics Bioinformatics. 2021. PMID: 33610792 Free PMC article.

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Corrigendum to "An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication" [Genomics Proteomics Bioinformatics19 (1) (2021) 108-122]

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Corrigendum to "An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication" [Genomics Proteomics Bioinformatics19 (1) (2021) 108-122]

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