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. 2023 Jan 20;10(1):45.
doi: 10.1038/s41597-023-01941-6.

Deep phenotyping and genomic data from a nationally representative study on dementia in India

Jinkook Lee  1 , Sarah Petrosyan  2 , Pranali Khobragade  2 , Joyita Banerjee  3 , Sandy Chien  2 , Bas Weerman  2 , Alden Gross  4 , Peifeng Hu  5 , Jennifer A Smith  6 , Wei Zhao  6 , Leon Aksman  7 , Urvashi Jain  8 , G S Shanthi  9 , Ravi Kurup  10 , Aruna Raman  10 , Sankha Shubhra Chakrabarti  11 , Indrajeet Singh Gambhir  11 , Mathew Varghese  12 , John P John  12 , Himanshu Joshi  12 , Parvaiz A Koul  13 , Debabrata Goswami  14 , Arunansu Talukdar  15 , Rashmi Ranjan Mohanty  16 , Y Sathyanarayana Raju Yadati  17 , Mekala Padmaja  17 , Lalit Sankhe  18 , Chhaya Rajguru  18 , Monica Gupta  19 , Govind Kumar  20 , Minakshi Dhar  21 , Jorge Jovicich  22 , Andrea Ganna  23 , Mary Ganguli  24 , Prasun Chatterjee  3 , Sunny Singhal  3 , Rishav Bansal  3 , Swati Bajpai  3 , Gaurav Desai  3 , Swaroop Bhatankar  25 , Abhijith R Rao  3 , Palanimuthu T Sivakumar  12 , Krishna Prasad Muliyala  12 , Preeti Sinha  12 , Santosh Loganathan  12 , Erik Meijer  2 , Marco Angrisani  2 , Jung Ki Kim  26 , Sharmistha Dey  27 , Perianayagam Arokiasamy  28 , David E Bloom  29 , Arthur W Toga  7 , Sharon L R Kardia  6 , Kenneth Langa  30 , Eileen M Crimmins  26 , Aparajit B Dey  3
Affiliations

Deep phenotyping and genomic data from a nationally representative study on dementia in India

Jinkook Lee et al. Sci Data. .

Abstract

The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is a nationally representative in-depth study of cognitive aging and dementia. We present a publicly available dataset of harmonized cognitive measures of 4,096 adults 60 years of age and older in India, collected across 18 states and union territories. Blood samples were obtained to carry out whole blood and serum-based assays. Results are included in a venous blood specimen datafile that can be linked to the Harmonized LASI-DAD dataset. A global screening array of 960 LASI-DAD respondents is also publicly available for download, in addition to neuroimaging data on 137 LASI-DAD participants. Altogether, these datasets provide comprehensive information on older adults in India that allow researchers to further understand risk factors associated with cognitive impairment and dementia.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Timeline of fieldwork for LASI-DAD.
Fig. 2
Fig. 2
Summary of concordance by SNP over 15 duplicate sample pairs, binned by minor allele frequency. (a) Distribution of minor allele frequency, b) mean of correlation of allelic dosage, (c) mean of concordance, (d) mean of minor allele concordance.
Fig. 3
Fig. 3
Allele frequency check for comparing study (x-axis) and reference panel (y-axis) alternate allele frequencies. The figure shows the imputation basis SNPs on all autosomes and X chromosome. All autosomes and X chromosome were submitted for the full set of 960 samples (i.e. no whole chromosome anomaly exclusions).
See this image and copyright information in PMC

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