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Review
. 2023 Jan 4;12(1):87.
doi: 10.3390/antibiotics12010087.

Antimicrobial Treatment of Staphylococcus aureus Biofilms

Felipe Francisco Tuon  1 , Paula Hansen Suss  1 , Joao Paulo Telles  2 , Leticia Ramos Dantas  1 , Nícolas Henrique Borges  1 , Victoria Stadler Tasca Ribeiro  1
Affiliations
Review

Antimicrobial Treatment of Staphylococcus aureus Biofilms

Felipe Francisco Tuon et al. Antibiotics (Basel). .

Abstract

Staphylococcus aureus is a microorganism frequently associated with implant-related infections, owing to its ability to produce biofilms. These infections are difficult to treat because antimicrobials must cross the biofilm to effectively inhibit bacterial growth. Although some antibiotics can penetrate the biofilm and reduce the bacterial load, it is important to understand that the results of routine sensitivity tests are not always valid for interpreting the activity of different drugs. In this review, a broad discussion on the genes involved in biofilm formation, quorum sensing, and antimicrobial activity in monotherapy and combination therapy is presented that should benefit researchers engaged in optimizing the treatment of infections associated with S. aureus biofilms.

Keywords: Staphylococcus aureus; antibiotic; biofilm; infections; therapeutic antibiofilm.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic examples of the types of Staphylococcus aureus infections.
Figure 2
Figure 2
Development of staphylococcal biofilm.
Figure 3
Figure 3
Development of Staphylococcus aureus biofilm on medical devices (orthopedic titanium screw).
Figure 4
Figure 4
Genes associated involved in the regulation of S. aureus biofilm formation.
See this image and copyright information in PMC

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