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. 2023 Jan 9;13(1):133.
doi: 10.3390/biom13010133.

Genetic Predisposition to Neurological Complications in Patients with COVID-19

Nikhil Shri Sahajpal  1   2 , Alex R Hastie  3 , Maximilian Schieck  4   5 , Ashis K Mondal  1 , Marc Felde  6 , Caspar I van der Made  7   8   9 , Janet S Chou  10 , Adrienne G Randolph  11   12 , Thomas Illig  4   5 , Michael C Zody  13 , Catherine A Brownstein  14 , Alan H Beggs  14 , Alexander Hoischen  7   8   9 , Alka Chaubey  3 , Ravindra Kolhe  1 ; COVID19hostgenomesv Consortium
Affiliations

Genetic Predisposition to Neurological Complications in Patients with COVID-19

Nikhil Shri Sahajpal et al. Biomolecules. .

Abstract

Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.

Keywords: COVID-19; genetic predisposition; neurological complications; optical genome mapping; rare SVs.

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Conflict of interest statement

A.H. and A.C. are salaried employees of Bionano Genomics Inc. R.K. has received honoraria, travel funding, and research support from Illumina, Asuragen, QIAGEN, Perkin Elmer Inc., Bionano Genomics, and BMS. N.S.S. owns limited personal stocks of Bioannao Genomics. A.H.B. has received funding from the NIH, MDA (USA), AFM Tele-thon, Alexion Pharmaceuticals Inc., Audentes Therapeutics Inc., Dynacure SAS, and Pfizer Inc. He has consulted and received compensation or honoraria from Asklepios BioPharmaceutical Inc., Audentes Therapeutics, Biogen, F. Hoffman-La Roche AG, GLG Inc., Guidepoint Global, and Kate Therapeutics and holds equity in Ballard Biologics and Kate Therapeutics.

Figures

Figure 1
Figure 1
A ~176.7 kb duplication of chr 6 (chr6:162887379–162481424) disrupting the PRKN gene in one patient (case 53). The red arrows indicate a tandem duplication.
Figure 2
Figure 2
A ~126.5 kb duplication of chr 7 (chr7:82404497–82531042) disrupting the CACNA2D1 gene in one patient (case 53). The red arrow indicates a tandem duplication.
Figure 3
Figure 3
A ~784.3 kb deletion of chr 4 (chr4:91654881–92444482) disrupting the GRID2 gene in one patient (case 23). The deletion is highlighted with the region in red.
See this image and copyright information in PMC

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