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Review
. 2023 Jan 10;12(1):108.
doi: 10.3390/biology12010108.

Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives

Zahirrah Begam Mohamed Rasheed  1 , Fazlina Nordin  2 , Wan Safwani Wan Kamarul Zaman  3 , Yuen-Fen Tan  4   5 , Nor Haslinda Abd Aziz  6   7
Affiliations
Review

Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future Perspectives

Zahirrah Begam Mohamed Rasheed et al. Biology (Basel). .

Abstract

Infertility could be associated with a few factors including problems with physical and mental health, hormonal imbalances, lifestyles, and genetic factors. Given that there is a concern about the rise of infertility globally, increased focus has been given to its treatment for the last several decades. Traditional assisted reproductive technology (ART) has been the prime option for many years in solving various cases of infertility; however, it contains significant risks and does not solve the fundamental problem of infertility such as genetic disorders. Attention toward the utilization of MSCs has been widely regarded as a promising option in the development of stem-cell-based infertility treatments. This narrative review briefly presents the challenges in the current ART treatment of infertility and the various potential applications of autologous MSCs in the treatment of these reproductive diseases.

Keywords: assisted reproductive technology; infertility; mesenchymal stem cells.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 2
Figure 2
The future autologous methods in tackling infertility issues in men and women. These methods include cell-free therapy using extracellular vesicles (EVs), very small embryonic-like stem cells (VSELs), and organoids or functional organ-on-a-chip (OOAC) models (Created with Biorender.com).
Figure 1
Figure 1
The possible mechanism of actions of bone-marrow stem cells (BMSCs), adipose tissue stem cells (ADSCs), menstrual stem cells (Men-SCs), endometrial MSCs, and germline-derived stem cells: spermatogonial stem cells (SSCs), oogonial stem cells (OSCs), and thecal stem cells in treating various male and female infertility problems (Created with Biorender.com).
See this image and copyright information in PMC

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