Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Dec 23;13(1):37.
doi: 10.3390/brainsci13010037.

Value of Antibody Determinations in Chronic Dysimmune Neuropathies

Stefano Tozza  1 , Emanuele Spina  1 , Aniello Iovino  1 , Rosa Iodice  1 , Raffaele Dubbioso  1 , Lucia Ruggiero  1 , Maria Nolano  1   2 , Fiore Manganelli  1
Affiliations
Review

Value of Antibody Determinations in Chronic Dysimmune Neuropathies

Stefano Tozza et al. Brain Sci. .

Abstract

Chronic dysimmune neuropathies encompass a group of neuropathies that share immune-mediated pathomechanism. Chronic dysimmune antibody-related neuropathies include anti-MAG neuropathy, multifocal motor neuropathy, and neuropathies related to immune attack against paranodal antigens. Such neuropathies exhibit distinguishing pathomechanism, clinical and response to therapy features with respect to chronic inflammatory demyelinating polyradiculoneuropathy and its variants, which represent the most frequent form of chronic dysimmune neuropathy. This narrative review provides an overview of pathomechanism; clinical, electrophysiological, and biochemical features; and treatment response of the antibody-mediated neuropathies, aiming to establish when and why to look for antibodies in chronic dysimmune neuropathies.

Keywords: anti-MAG neuropathy; autoimmune paranodopathies; chronic dysimmune neuropathy; multifocal motor neuropathy with conduction block.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Bergh P.Y.K.V.D., Doorn P.A., Hadden R.D.M., Avau B., Vankrunkelsven P., Allen J.A., Attarian S., Blomkwist-Markens P.H., Cornblath D.R., Eftimov F., et al. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force—Second revision. J. Peripher. Nerv. Syst. 2021;26:242–268. doi: 10.1111/jns.12455. - DOI - PubMed
    1. Mahdi-Rogers M., Hughes R.A.C. Epidemiology of chronic inflammatory neuropathies in southeast England. Eur. J. Neurol. 2013;21:28–33. doi: 10.1111/ene.12190. - DOI - PubMed
    1. Vallat J.-M., Magy L., Ciron J., Corcia P., Le Masson G., Mathis S. Therapeutic options and management of polyneuropathy associated with anti-MAG antibodies. Expert Rev. Neurother. 2016;16:1111–1119. doi: 10.1080/14737175.2016.1198257. - DOI - PubMed
    1. Kuijf M.L., Eurelings M., Tio-Gillen A.P., van Doorn P.A., Berg L.H.V.D., Hooijkaas H., Stork J., Notermans N.C., Jacobs B.C. Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. Neurology. 2009;73:688–695. doi: 10.1212/WNL.0b013e3181b59a80. - DOI - PubMed
    1. Trapp B.D. Myelin-Associated Glycoprotein Location and Potential Functions. Ann. N. Y. Acad. Sci. 1990;605:29–43. doi: 10.1111/j.1749-6632.1990.tb42378.x. - DOI - PubMed