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Review
. 2023 Jan 3;11(1):118.
doi: 10.3390/biomedicines11010118.

mRNA Metabolism and Hypertension

Martina Zappa  1 , Paolo Verdecchia  2   3 , Antonio Spanevello  1   4 , Michele Golino  1 , Fabio Angeli  1   4
Affiliations
Review

mRNA Metabolism and Hypertension

Martina Zappa et al. Biomedicines. .

Abstract

Hypertension is the most frequent cardiovascular risk factor all over the world. It remains a leading contributor to the risk of cardiovascular events and death. In the year 2015, about 1.5 billion of adult people worldwide had hypertension (as defined by office systolic blood pressure ≥ 140 mmHg or office diastolic blood pressure ≥ 90 mmHg). Moreover, the number of hypertensive patients with age ranging from 30 to 79 years doubled in the last 30 years (from 317 million men and 331 million women in the year 1990 to 652 million men and 626 million women in 2019) despite stable age-standardized prevalence worldwide. Despite such impressive growth, the proportion of controlled hypertension is very low. A better understanding of the pathogenesis of hypertension may contribute to the development of innovative therapeutic strategies. In this context, alterations of the messenger RNA metabolism have been recently evaluated as contributors to the pathogenesis of hypertension, and pharmacological modulation of RNA metabolism is under investigation as potential and novel therapeutic armamentarium in hypertension.

Keywords: blood pressure; chronic disease; hypertension; mRNA; metabolism.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the renin-angiotensin-aldosterone system. ACE: Angiotensin Converting Enzyme, H2O: chemical formula for water, NaCl: chemical formula for sodium chloride. See text for details.
Figure 2
Figure 2
Potential sites of RNA modifications. DNA: deoxyribonucleic acid, RNA: ribonucleic acid. See text for details.
See this image and copyright information in PMC

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