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Review
. 2023 Jan 5;24(2):1057.
doi: 10.3390/ijms24021057.

The Role of MicroRNAs in Pancreatitis Development and Progression

Hetvi R Patel  1 , Vanessa M Diaz Almanzar  1 , Joseph F LaComb  1 , Jingfang Ju  2 , Agnieszka B Bialkowska  1
Affiliations
Review

The Role of MicroRNAs in Pancreatitis Development and Progression

Hetvi R Patel et al. Int J Mol Sci. .

Abstract

Pancreatitis (acute and chronic) is an inflammatory disease associated with significant morbidity, including a high rate of hospitalization and mortality. MicroRNAs (miRs) are essential post-transcriptional modulators of gene expression. They are crucial in many diseases' development and progression. Recent studies have demonstrated aberrant miRs expression patterns in pancreatic tissues obtained from patients experiencing acute and chronic pancreatitis compared to tissues from unaffected individuals. Increasing evidence showed that miRs regulate multiple aspects of pancreatic acinar biology, such as autophagy, mitophagy, and migration, impact local and systemic inflammation and, thus, are involved in the disease development and progression. Notably, multiple miRs act on pancreatic acinar cells and regulate the transduction of signals between pancreatic acinar cells, pancreatic stellate cells, and immune cells, and provide a complex interaction network between these cells. Importantly, recent studies from various animal models and patients' data combined with advanced detection techniques support their importance in diagnosing and treating pancreatitis. In this review, we plan to provide an up-to-date summary of the role of miRs in the development and progression of pancreatitis.

Keywords: autophagy; microRNA; pancreatic stellate cells; pancreatitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
MiR-9, 146-3p, 365-3p, and 183-5p in the regulation of inflammatory response during acute pancreatitis role (please see text for details). Created with BioRender.com.
Figure 2
Figure 2
MiR-92-3p, 146a-5p, and 148a in the regulation of inflammatory response and autophagy during acute pancreatitis (please see text for details). Created with BioRender.com.
Figure 3
Figure 3
MiRs’ role in tight junctions in SAP (please see text for details). Created with BioRender.com.
Figure 4
Figure 4
MiRs regulating inflammation and immune response in SAP (please see text for details). Created with BioRender.com.
Figure 5
Figure 5
HDAC/miR-15/16 axis regulates the activation of PSCs in CP (please see text for details). Created with BioRender.com.
Figure 6
Figure 6
TGFβ/ln-PFAR/miR-141-5p axis regulates the activation of PSCs in CP (please see text for details). Created with BioRender.com.
Figure 7
Figure 7
MiR-21 plays a crucial role in the activation, glycolysis, fibrosis, migration, and invasion of PSCs in CP (please see text for details). Created with BioRender.com.
See this image and copyright information in PMC

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