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Review
. 2023 Jan 10;24(2):1374.
doi: 10.3390/ijms24021374.

Spotlight on P2X7 Receptor PET Imaging: A Bright Target or a Failing Star?

Stephan Schmidt  1 , Andreas Isaak  1 , Anna Junker  1
Affiliations
Review

Spotlight on P2X7 Receptor PET Imaging: A Bright Target or a Failing Star?

Stephan Schmidt et al. Int J Mol Sci. .

Abstract

The homotrimeric P2X7 receptor (P2X7R) is expressed by virtually all cells of the innate and adaptive immune system and plays a crucial role in various pathophysiological processes such as autoimmune and neurodegenerative diseases, inflammation, neuropathic pain and cancer. Consequently, the P2X7R is considered a promising target for therapy and diagnosis. As the development of tracers comes hand-in-hand with the development of potent and selective receptor ligands, there is a rising number of PET tracers available in preclinical and clinical studies. This review analyzes the development of P2X7R positron emission tomography (PET) tracers and their potential in various PET imaging applications.

Keywords: CNS; P2X; PET tracer; PNS; antagonists; glioma; imaging; neuroinflammation; purinergic P2X7 receptor (P2X7R).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Examples of radiosyntheses of [11C]GSK1482160 [18F]-JNJ-64413739 [68,70].
Figure 1
Figure 1
(A) Overview of different P2X7R antagonists divided by targeting either the CNS or the peripheral nervous system. (B) Common representatives of different structural classes of imaging compounds. Radioisotopes are highlighted with different colors.
See this image and copyright information in PMC

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